Doctoral (PhD) student position in normal and malignant hematopoiesis Full-time NEW

Doctoral (PhD) Student Position in Normal and Malignant Hematopoiesis

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The Research Group

Dahlin's team focuses on charting basophil and mast cell differentiation at the single-cell level in health and hematologic diseases. This is performed using state-of-the-art single-cell omics technologies complemented with functional experiments. The current team consists of the principal investigator and four doctoral students, which together cover the areas of experimental research, bioinformatics, and applied mathematics. The group is part of the Division of Immunology and Respiratory Medicine.

The Doctoral Student Project and the Duties of the Doctoral Student

The differentiation of hematopoietic stem cells into the various blood cell lineages has been described with high precision. However, the basophil differentiation trajectory has yet to be charted in detail. The mission of the doctoral student project is to map basophil differentiation in health and hematologic disease. This includes studies of how progenitor cell fate is regulated at the molecular level during differentiation, and investigations of how disease-associated genetic alterations affect hematopoiesis and basophil development.

Key technologies applied to primary samples from healthy subjects and patients with hematologic diseases include FACS sorting, flow cytometry-based analysis, CRISPR-based gene editing, cell culture and cell fate assays, cytochemical staining, and single-cell omics technologies, including transcriptomics and surface epitope profiling. The research is performed in an interdisciplinary setting, with both experimental and computational scientists. It also includes collaborations with clinical departments as well as national and international research groups.

The main focus of the doctoral studies is experimental research, though the doctoral student will also be involved in omics data analysis performed together with bioinformaticians and applied mathematicians in the group. Additional duties include participation in daily routines of the research group and the division, such as shared laboratory tasks, administration, and supervision.

What Do We Offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility Requirements for Doctoral Education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and Personal Qualities

Previous experience with experimental work is required.

Experience from research projects involving cell biology, molecular biology, immunology, hematology, biotechnology, or related fields is considered an advantage.

The successful applicant is motivated, trustworthy, organized, curious and open-minded, and has good collaborative skills.

Terms and Conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application Process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

• A personal letter, in Swedish or English, describing why you are interested in the doctoral project. The letter should also include concrete examples of how your knowledge, skills, and previous experience make you suitable for this particular position.
• Curriculum vitae
• Degree projects and previous publications, if any
• Any other documentation showing the desirable skills and personal qualities described above
• Documents certifying your general eligibility (see A above)
• Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research – Analytical skill – Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.