Postdoctoral training opportunity
PI: David MacPherson, Professor, Fred Hutchinson Cancer Research Center, Seattle, WA, email: firstname.lastname@example.org
Our lab is focused on the biology of small cell lung cancer (SCLC). We apply functional screens and analyses of genetically engineered mouse (GEM) and patient-derived xenograft (PDX) models towards understanding genes mutated in SCLC and the basis of response towards conventional and novel therapies. Our lab works closely with thoracic oncologist collaborators at the Seattle Cancer Care Alliance to access patient samples and to help translate basic findings (e.g. see Augert et al, 2019, Science Signaling “Targeting NOTCH Activation in Small Cell Lung Cancer Through LSD1 Inhibition”). Some of these directions are supported by an NIH Lung Cancer SPORE award that promotes translational lung cancer research. We are also interested in understanding basic mechanisms underlying SCLC tumor suppressor function (e.g., see Augert et al, 2020 Cancer Cell 2020, “MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer” and Jia et al, 2018, Cancer Discovery “Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition”). We currently make extensive use of functional screens performed in vivo and in tissue culture cells to understand genes important for SCLC and to identify new druggable vulnerabilities. We are also interested in finding ways to improve immune-based therapies for SCLC.
The specific project will be developed by both the candidate and Dr. MacPherson based on areas of shared interests.
Recent PhD in Biology or related fields
Excellent oral and written communication skills
Must be able to design and execute experiments, interpret data and present results
A record of publication in peer-reviewed journals
Tagged as: Life Sciences
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