Junior Specialist, Buchwalter Laboratory, Cardiovascular Research Institute Full-time

Junior Specialist, Buchwalter Laboratory, Cardiovascular Research Institute

The Buchwalter laboratory seeks a Junior Specialist to join the team at the Cardiovascular Research Institute on UCSF's Mission Bay campus. This position has a desired start date around October 1, 2026. We are working to understand the function and dynamic regulation of the nuclear lamina, which is a structure found at the edge of most eukaryotic nuclei that strengthens the nucleus and influences genome organization and gene expression. Our interest is motivated by hints that the lamina is essential for normal development, and by the existence of a group of rare diseases known as “laminopathies” that are linked to mutations in the Lamin proteins.

Our mission is to make meaningful contributions to science while fostering a laboratory culture that values both individual growth and effective teamwork. We believe that making scientific discoveries requires the audacity to question existing knowledge and the confidence to explore the unknown. “Success” to us means empowering each lab member to discover.

The Junior Specialist will work under the guidance of the Principal Investigator (Abby Buchwalter) and under the day-to-day mentorship of a senior researcher in the Buchwalter laboratory.

The Buchwalter lab is a team of ~8 students and postdocs. The Junior Specialist will have the opportunity to support an ongoing project that will involve experimental workflows such as:

• Molecular biology: RNA and DNA extractions, cloning, mutagenesis, quantitative PCR, and Western blotting
• Next generation sequencing workflows: library preparation and sequencing
• Bioinformatic workflows for analysis of next generation sequencing and/or proteomic data
• Stem cell culture: CRISPR editing, stem cell culture, directed differentiation, and fluorescence microscopy of human induced pluripotent stem cells (hiPSCs)

Candidates for the Junior Specialist rank must possess a Bachelor's degree in the life sciences with at least one year of laboratory experience, by the time of hire. Applicants' materials must list current and/or pending qualifications upon submission. The ideal candidate would have experience with molecular cloning and cell culture. However, we value curiosity, creativity, strong analytical and organizational skills, and the motivation to work both independently and to support the goals of the team above specific technical experience.

Click here to apply with a short cover letter describing your background and interests, a CV or resume, and contact information for 2 references. Informal inquiries to Dr. Abby Buchwalter are welcome (abigail.buchwalter@ucsf.edu) but formal applications must be submitted through AP Recruit.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $57,000 – $60,700.

Application Requirements:

• Curriculum Vitae – CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.).
• Cover Letter – a short cover letter describing your background and interests
• Statement of Research (Optional)
• Statement of Teaching (Optional)

• 2 required (contact information only)

About UC San Francisco:

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct. • “Misconduct” means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, or discrimination, as defined by the employer. • UC Sexual Violence and Sexual Harassment Policy • UC Anti-Discrimination Policy • APM – 035: Affirmative Action and Nondiscrimination in Employment

Job location: San Francisco, CA