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Scientist
Toxicologist II with cell culture and DMPK experience Full-time
Description:
The Screening and Assay Development group seeks two graduates (MS or higher) in Toxicology, Toxicological Sciences or a related discipline, with experience in cell-based assays and HTS. The primary responsibility will be to conduct chemical testing and interpret PK data and mechanism-informing toxicity data from the in vitro assays. The preferred candidate would have extensive experience with high-throughput screening (HTS), ADME/drug metabolism enzyme (DME) assays, solid understanding of biochemical pathways and enzyme kinetics, and expert knowledge of cell culture. Experience with microsomal DME assays and vesicle-based transporter assays is a plus, but not required.
Qualifications:
• Hands-on experience with cell-based toxicity assays
• Ability to interpret pharmacokinetic data from in vitro studies
• Knowledge of major DMEs (CYP450s, UGTs, etc.) and transporters
• Ability to apply biochemical principles to drug metabolism and toxicology
• Proficiency in cell culture techniques (e.g., cell maintenance, passaging, differentiation etc.)
• Experience with primary cells, iPSCs and cell lines
• Proficiency in standard laboratory techniques and HTS
• Experience with data analysis and statistical computation (R or GraphPad Prism, Python)
• Ability to execute, troubleshoot and analyze experiments and to interpret results
• Familiarity or experience with machine learning
• Documentation of procedures and results in compliance with Electronic Lab Notebook guidelines
• Strong interpersonal and organizational skills
• Ability to work in a fast-paced environment
• Excellent oral, written and presentation skills
• Willingness to travel and present at conferences
• MS or PhD in a relevant scientific discipline
Employment requirements:
• At least three references.
• Successfully completed background check.
Confidentiality:
Your information will be kept confidential according to EEO guidelines.