Postdoc/Scientist – Psychiatry and Neuronal Health Full-time

Postdoctoral Research Fellow

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Position Summary

The Psychiatry and Neuronal Health group at Eli Lilly is seeking a highly motivated Postdoctoral Research Fellow to join an active in vivo pharmacology program studying reward, arousal, and stress-related neural circuitry. The successful candidate will apply circuit-level tools, including fiber photometry, microdialysis, and behavioral pharmacology models, to characterize neuromodulatory signaling relevant to CNS drug discovery.

Key Responsibilities

• Design and execute in vivo experiments in rodent behavioral models relevant to CNS drug discovery, including chronic IV self-administration, extinction, and cue-induced reinstatement paradigms
• Perform rodent survival surgeries: stereotaxic viral injection, IV catheter implantation, and fiber optic cannula placement
• Perform single- and dual-site in vivo fiber photometry recordings (genetically encoded calcium and/or neuropeptide biosensors) to characterize real-time circuit dynamics during behavior, including during cue-triggered reinstatement testing
• Conduct in vivo microdialysis paired with LC/MS or immunoassay quantification to measure neurotransmitter/neuropeptide efflux across relevant brain nuclei
• Apply circuit-dissection techniques to map projections and test causal sufficiency/necessity in the behaviors under study
• Perform multiplex fluorescence and routine histological experiments
• Characterize sleep/arousal architecture (EEG/EMG) as relevant to project needs
• Support processing and molecular analysis of human postmortem brain tissue, including coordination with external tissue repositories
• Analyze and interpret multimodal datasets (behavioral, neurochemical, imaging, transcriptomic) using established computational pipelines
• Author manuscripts for peer-reviewed publication and present findings at internal reviews and external scientific conferences
• Maintain rigorous documentation, IACUC protocol compliance, and data integrity standards

Required Qualifications

• Ph.D. (or equivalent) in Neuroscience, Pharmacology, Behavioral Neuroscience, or a closely related field, completed within the last 1–3 years (or near completion)
• Hands-on experience with in vivo fiber photometry (calcium/neuropeptide sensor recording, signal processing, and analysis)
• Demonstrated expertise in rodent stereotaxic surgery, viral vector delivery, and fiber optic cannula implantation
• Experience with rodent operant/behavioral pharmacology models (IV self-administration, extinction, and/or cue reinstatement paradigms strongly preferred; IV catheterization experience a plus)
• Familiarity with in vivo microdialysis and downstream analytical quantification (HPLC/LC-MS or similar)
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Preferred Qualifications

• Working knowledge of reward, arousal, and/or stress-related neurocircuitry
• Proficiency in behavioral pharmacology and rodent handling (rat and/or mouse)
• Strong quantitative/analytical skills (MATLAB, Python, or R for photometry/behavioral data analysis)
• Track record of first-author publications in peer-reviewed journals
• Excellent written and verbal communication skills
• Experience with optogenetics and/or chemogenetics for circuit manipulation
• Experience with unbiased stereology
• Experience with multiplex fluorescence and in situ hybridization
• Experience with dual-site or multi-site simultaneous fiber photometry recording
• Experience with EEG/EMG sleep-wake scoring and vigilance state analysis
• Experience with genetically encoded biosensors

What We Offer

• A mentored postdoctoral appointment with a defined project, dedicated supervisor, and co-supervisor support
• Access to Lilly's internal drug discovery infrastructure, compound libraries, and cross-functional scientific expertise
• Strong publication support and encouragement to present at national/international conferences
• Competitive stipend and benefits per Lilly postdoctoral program guidelines
• Clear pathway for scientific development toward independent research or industry drug discovery careers