Postdoctoral position in epigenomic data analysis Full-time NEW

Postdoctoral Position In Epigenomic Data Analysis

Are you interested in working with epigenomic datasets in the context of chemical hazards and human health in a friendly, thriving, international environment? Join the Molecular Toxicology and Epigenetics (EpiTox) group at the Department of Organismal Biology, working on epigenomic and other molecular profiling to uncover mechanisms underlying (neuro) developmental effects of endocrine disrupting chemicals (EDCs). The EpiTox group is part of the research program Physiology and Environmental Toxicology, a growing, vibrant research environment where experimental models and molecular tools are used to study and understand cellular and molecular mechanisms in animals and plants underlying whole organisms' physiology, development, and responses to the environment. You will work within the EU-funded projects RE-MEND and ExpoSignalz. These are interdisciplinary projects involving multiple partners and focusing on mental health and neurodegeneration, respectively. In both projects, the role of the EpiTox group is to identify epigenetic markers of exposure-induced effects on the brain using different experimental models.

Duties: You will perform bioinformatic and biostatistical analyses of various epigenomic datasets generated using Oxford Nanopore sequencing (DNA modifications) from mouse and zebrafish models. The work will also involve multi-omics integration. In addition, you will contribute to the preparation of scientific publications, project reports, and presentations of research findings at project meetings and international conferences. You are expected to independently plan, conduct, analyze, and interpret your research. You will also provide support and guidance to PhD and Master's students and actively participate in the scientific and social activities of the research group, program, and department.

Requirements: PhD degree or a foreign degree equivalent to a PhD degree in bioinformatics, biostatistics, computational biology or fields deemed as similar by the employer. The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment. The starting point of the three-year frame period is the application deadline. Due to special circumstances, the degree may have been obtained earlier. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc. Well-documented experience working with R or python, analysis of long read sequencing and DNA methylation data sets and knowledge about statistical analyses of such data and on environmental epigenomics is required. As the work will be carried out in an international interdisciplinary environment, excellent oral and written communication skills in English are required.

Additional qualifications: As there may be a need to prepare new sequencing libraries, experience with molecular biology laboratory techniques, particularly Oxford Nanopore library preparation, is desirable. Experience in multi-omics data integration is also considered a strong advantage. Emphasis will also be placed on personal qualities. We seek a highly motivated person with original, creative and analytical thinking and team spirit. The applicant is expected to take initiative and work independently.

About the employment: The employment is a temporary position of 2 years according to central collective agreement with the possibility of 1year extension. Scope of employment 100 %. Starting date as agreed. Placement: Dept. of Organismal Biology, Evolutionary Biology Centre, Uppsala University.

For further information about the position, please contact: Joëlle Rüegg, joelle.ruegg@ebc.uu.se