Postdoctoral Research Associate (Fundamental Tumor Immunology) – Radiation Oncology Full-time

Postdoctoral Researcher Position

A postdoctoral researcher position is available in the tumor immunology laboratory of Dr. Sana Karam, professor of radiation oncology at WashU Medicine. Situated within the world-renowned WashU Bursky Center for Human Immunology ecosystem, our federally funded research program is fundamentally rooted in basic immunology and cancer biology. We rigorously investigate systemic immunity, the tumor microenvironment (TME), and the mechanistic drivers of resistance to radiation and immunotherapy utilizing advanced pre-clinical models of head/neck and pancreatic cancers.

While our core identity is grounded in fundamental, mechanistic discovery, we possess the rare and privileged ability to directly translate our bench findings into real-time clinical trials. The Karam Lab has a proven, established track record of mentoring postdoctoral fellows into successful independent research careers. We are seeking our next scientific leader.

As our basic science and pre-clinical research programs continue to expand, we are specifically seeking a candidate with rigorous, formal training in fundamental immunology to drive the in vivo and molecular arm of our lab. While the PI remains deeply engaged in the strategic vision and intellectual mentorship of the laboratory, we operate on a model of high-level scientific partnership rather than traditional bench-level micromanagement. You are expected to bring deep mechanistic insight, drive the scientific narrative, and leverage our robust pre-clinical models—complemented by our clinical trial multi-omic data—to build your own high-impact portfolio. This position is designed as a launchpad for an ambitious postdoc intending to build their own independent laboratory.

We are seeking a highly driven, intellectually rigorous, and fiercely curious scientist. The successful candidate must possess a deep hunger for scientific discovery, the ability to think critically and independently, and the ambition to push the boundaries of current oncologic paradigms. Supported by in-house computational biologists and top-tier institutional core facilities, your primary mandate will be high-level hypothesis generation, designing and executing complex mechanistic in vivo models, and driving science forward to high-impact publication.

Primary duties and responsibilities include:

• Intellectual leadership: independently formulate hypotheses regarding systemic immune responses, TME reprogramming, macrophage polarization, and T-cell exhaustion to overcome treatment resistance.
• Self-directed scientific execution: this laboratory operates on a model of high autonomy and intellectual partnership. The successful candidate will not wait for directives; rather, they are expected to independently identify scientific gaps, propose robust experimental designs, and drive projects forward to completion. You will act as the intellectual engine for our mechanistic immunology studies.
• Advanced execution: design and execute highly complex, fundamental basic science and translational experiments utilizing orthotopic models, targeted radiation platforms (SARRP), and advanced immunological assays.
• Scientific communication: take aggressive ownership of your projects. Analyze data rigorously, draft high-impact manuscripts, and write grant applications (e.g., K99/R00, F32, or foundational grants).
• Collaborative mentorship: engage in high-level scientific discourse with our senior scientists, computational biologists, and graduate students to elevate the overall intellectual rigor of the lab.
• Elite mentorship & team science: serve as the day-to-day scientific sounding board and technical mentor for top-tier MSTP and PhD students. You will guide these trainees in advanced immunological techniques and experimental design, effectively acting as a team leader to multiply your own scientific output.

Working conditions: this position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary range: base pay is commensurate with experience.

Applicant special instructions:

• a specialized cover letter explicitly detailing your most significant scientific intellectual contribution to date, your career ambitions, and a description of why you thrive in a highly independent environment that values peer-level scientific discourse over day-to-day directive instructions.
• curriculum vitae (CV) including a full list of publications.
• contact information for three professional references.