Postdoctoral researcher in adipose tissue vascular biology Full-time

Postdoctoral Researcher In Adipose Tissue Vascular Biology

Are you curious why obesity leads to cardiometabolic disease, and want to contribute to elucidating the underlying disease mechanisms? We are a dynamic research group working translationally to understand how expansion of the human white adipose tissue leads to the emergence of cardiometabolic diseases, most notably dyslipidaemia and insulin resistance. As a part of a larger network of researchers in metabolism and cardiovascular inflammation, our lab aims to identify early molecular mechanisms driving disease initiation during obesity, with a particular focus on better understanding the source of adipose tissue dysfunction.

The postdoctoral project will study the dynamics of the endothelial barrier in white adipose tissue and how it shapes adipose tissue lipid handling in health and disease. You will combine humanized in vitro models, made up of primary human microvascular endothelial cells or unilocular adipocyte spheroids, with functional in vivo mouse experiments. Omics analyses will complement these approaches, and the project will involve close collaboration with national and international partners, as well as colleagues in the lab working on adjoining projects.

We are seeking a curious, motivated, creative, and independent researcher with a recent PhD and a strong background in experimental vascular biology and adipose tissue research, ideally demonstrated by several publications in well-established journals.

Required qualifications:

• Hands-on experience of culture and transwell-models using primary endothelial cells
• 3D in vitro spheroids models of adipose tissue
• Experience from in vivo mouse work, including i.v. tracing experiments in mice, and image-based analysis of tracer accumulation in organs, GTT and ITT.
• The ability to plan, perform, analyse and document animal experiments as well as maintain animal colonies.
• Excellent communication skills in both spoken and written English

Meriting qualifications:

• The ability to work in a team and help out colleagues both experimentally and by discussing.
• Omics analyses of transcriptomics data

Scientific expertise and an ambitious, driving and problem-solving attitude with an attention to detail are highly valued.

To be eligible for employment as a postdoctor, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered an advantage if you have completed your doctoral degree within the last three years. If there are special reasons, your degree may have been completed earlier.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

The position is located within the Department of Medicine, Solna. The department consists of ten divisions and each division consists of several research groups. The position is located within the research group headed by Associate Professor Carolina Hagberg in an international group consisting of 12 people, working as an integrated part of the larger Cardiovascular Theme that comprises around 100 persons active both in basic and translational research. Our lab is located in the brand-new research building BioClinicum at the heart of KI's Solna campus, with close proximity to both the clinics at the Karolinska Hospital and the research resources of Karolinska Institutet. We are also affiliated to the Centre for Molecular Medicine (CMM) that offer an excellent variety of core facilities and researcher support.

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T

The application is to be submitted through the Varbi recruitment system.