Postdoctoral researcher in cardiometabolic vascular disease Full-time

Postdoctoral Researcher In Cardiometabolic Vascular Disease

Do you want to contribute to top quality medical research?

We are seeking a highly motivated and ambitious individual to join the research group (Division of Cardiology) of Associate Professor Zhichao Zhou as a Postdoctoral Fellow to investigate novel disease mechanisms underlying diabetes-associated cardiovascular complications and identify new therapeutic targets and reliable biomarkers to prevent cardiovascular dysfunction and predict cardiovascular events.

We are located in a modern research hub called BioClinicum at Karolinska Institutet in Solna where you will be working in an international and interdisciplinary research environment. Together with other research groups, the Cardiovascular Theme offers state-of-the art cell culture, molecular biology, functional analysis and microscopy facilities.

Your Mission

The vascular complication in cardiometabolic disease research group led by Associate Professor Zhichao Zhou at Division of Cardiology, Department of Medicine, Solna has a postdoc position in cardiovascular research open for a highly motivated scientist. The project is focused on problems related to type 2 diabetes-associated vascular complications. The aim of this project is to characterize the function of red blood cell-derived non-coding RNAs in the development of vascular dysfunction in type 2 diabetes. Studies are designed using a combination of clinically-based and molecular mechanistic investigations. Materials from well-characterized patients with type 2 diabetes, rodent diabetic models, gene-modified mouse models and cell models are used. Research projects involve in vitro (including isolation of red blood cells, extracellular vesicles and animal tissues, cell culture, immunohistochemistry, Western blot and qPCR), ex vivo (vessel reactivity assessment with Wire myograph) and in vivo experimental methods (including rat and mouse work).

Your Profile

Applicants should have:

• A strong research background in experimental and/or translational cardiovascular research documented by publications of studies related to cardiovascular disease and vascular biology.
• Experience from studies of isolated arteries and/or animal work.
• Experience from laboratory methods including Western blotting, immunohistochemistry, and cell cultures is expected.

Meritorious:

• Previous experience (documented experience) with non-coding RNA study.

We welcome a creative, hardworking, and enthusiastic team-player to our dynamic research group. The candidate is expected to take part in experimental design, experimentation, presentation, and preparation of publications. The candidate should have good social and communication skills as well as good spoken and written English language level, to effectively integrate in the research group.

To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

What Do We Offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location

The position is located within the Department of Medicine, Solna. The department consists of ten divisions, and each division consists of several research groups. The position is located within the research group of Zhichao Zhou at BioClinicum. The research group carries out translational research focusing on novel disease mechanisms and treatment of cardiovascular complications in cardiometabolic disorder and diabetes. Our focus is to explore scientific problems of high clinical relevance for cardiovascular disease.

Application

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T

The application is to be submitted through the Varbi recruitment system.