Postdoctoral Researcher in Mitochondria Biology Full-time

Postdoctoral Researcher in Mitochondria Biology

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

Do you want to contribute to top quality medical research?

Our group at the Division of Neurogeriatrics, Karolinska Institutet, study how mitochondrial function and dynamics influence early disease mechanisms in Alzheimer's disease. Our team combines advanced cell biology, super-resolution imaging, and in vitro and in vivo models to better understand how brain energy metabolism fails during neurodegeneration. By joining our group, you will gain hands-on experience with cutting-edge neuroscience research in an international and collaborative environment.

The position is a full-time fixed-term employment for two years, with a possibility of extension.

Your mission

This project aims to generate a spatially resolved map of mitochondrial functions, network organization, and dynamics in a 3D model of Alzheimer's disease. Our ambition is to identify key events that regulate and precede mitochondrial decay during neurodegeneration.

The project combines 2D and 3D cell culture systems, confocal and super-resolution live imaging microscopy, high-resolution respirometry, and deep learning-based image analysis. You will be involved in experimental work, data analysis, supervision of junior researchers, and grant writing, while contributing to the collaborative scientific environment of the group.

Your profile

We are seeking a highly motivated and team-oriented postdoctoral researcher with a background in neuroscience and a strong interest in mitochondrial biology. The successful candidate must have documented experience in advanced fluorescence imaging, including confocal and/or super-resolution microscopy of mitochondria and other relevant organelles such as lipid droplets and lysosomes. Experience with primary neural cultures, brain organoid systems, and image analysis is essential. Strong computational and coding skills are also essential, particularly for microscopy image analysis and handling large datasets. Proficiency in programming languages such as Python or R is expected, and experience with deep learning–based image analysis approaches is highly desirable.

The candidate is expected to work independently, perform experiments and data analysis, and actively contribute to the scientific development of the group. Participation in supervision and collaborative projects is also expected.

Training in laboratory animal science according to FELASA guidelines (or equivalent) is required. Fluency in written and spoken English is mandatory.

To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: We are located in BioClinicum, KI-Campus Solna.

Application

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

The evaluation of applications and recruitment process will begin after the summer break.