Postdoctoral Scientist in Molecular biology of Neoantigen pMHC-TCR Interactions in Sarcoma Full-time NEW

Postdoctoral Scientist in Molecular Biology of Neoantigen pMHC-TCR Interactions in Sarcoma

Sir William Dunn School of Pathology, South Parks Road, Oxford

We are seeking a highly motivated post-doctoral scientist with a PhD/DPhil for molecular research that extends neoantigen prediction, TCR selection and pMHC-TCR molecular and cellular interactions. The focus is on neoantigens associated with chromosomal translocations in rare cancers (sarcoma). The post is funded by collaborative grants that aim to develop the basic science and experimental basis for translation of pMHC-TCR interactions to personalized TCR therapies. The post-holder will be located at the Sir William Dunn School of Pathology and must be able to work independently within a multi-disciplinary research group and in collaboration.

The post-holder will be responsible for managing their own academic research, adapting existing and developing new scientific techniques and experimental protocols. You will work to identify, develop, modify and apply the necessary techniques such as mammalian and bacterial protein expression, surface plasmon resonance and T-cell reporter assays to achieve the goals of the project. The post-holder should be able to present detailed research proposals to senior researchers, present at scientific meetings, be familiar with I.P. and write up the results for publication in peer-reviewed journals.

The post-holder should either hold or be very close to completion of a PhD/DPhil directly relevant to this specific post preferably with experience equivalent to a post-doctoral level. You should have expertise in laboratory molecular and cell biology techniques. You should have proven skills in working independently to solve experimental problems and be capable of high-quality research supervision as a member of a group, as demonstrated by significant research outputs through publications, patents and conference proceedings.

This is a fixed-term appointment available for up to 24 months in the first instance starting from the 1st of October 2026. If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for applications is 12:00 on 4 September 2026. Interviews will be held mid-September online. Candidates will be asked to give a 10-minute research talk in the interview. For further details, please contact Prof Bass Hassan via email.