Postdoctoral studies in regulatory genomics in neuroscience (scholarship) Full-time NEW

Postdoctoral Studies In Regulatory Genomics In Neuroscience (Scholarship)

The Llorens laboratory offers a vibrant, stimulating and international environment. We are part of the Department of Cell and Molecular Biology at the Karolinska Institute in Stockholm, Sweden, one of the world's leading medical universities. The lab is located in Biomedicum, one of Europe's largest laboratories with ultramodern facilities and rich opportunities for collaboration and career development.

Our lab is interested in stimulating regeneration in the mammalian central nervous system (CNS). We aim to uncover the principles of gene expression regulation during development and repurpose them for regeneration. We use a multidisciplinary approach that involves glial biology, genomics, molecular engineering and animal models of disease.

In recent work, we recently discovered a latent regenerative potential in adult spinal cord stem cells using single cell multiomics and designed a targeted intervention to elicit such potential (Llorens-Bobadilla et al. Science 2020). In parallel, we also develop novel technologies for spatially-resolved multiomics (Llorens-Bobadilla et al. Nature Biotech 2023) and sequence to function genomics modeling to interrogate and specifically perturb injury-induced programmes (Zamboni et al. Nature Neurosci. 2026).

The current projects aim at using computational modelling of multiomic single cell and spatial genomics datasets, to uncover principles of gene expression regulation during CNS injury and repurpose them for regeneration using synthetic genomics.

We are seeking a highly motivated and enthusiastic postdoctoral fellow to apply and develop advanced computational methods to cutting-edge single-cell and spatial genomics approaches to uncover mechanisms of neural circuit repair and regeneration. The candidate will integrate large-scale transcriptomic and epigenomic datasets across species with state-of-the-art deep learning models to link sequence to function, supporting the design of regenerative therapies in the nervous system. The successful candidate will interact with experimentalists to combine data-driven analysis with subsequent in vivo perturbations.

We are looking for a highly motivated, self-driven computational biologist with a strong track record and relevant experience from PhD and/or previous postdoctoral work. A strong publication record and a recently completed PhD will be considered advantageous. The successful applicant is expected to have a background and strong interest in one or several of the following areas: computational biology, machine learning, single-cell and/or spatial multiomics, bioinformatics, and gene regulation. Prior experience with deep learning applied to multiomics datasets is a plus. Good communication skills in spoken and written English are required.

• You hold a PhD degree in Bioinformatics, Artificial Intelligence, Computer Science, Bio-engineering, or an equivalent discipline.
• Experience with high performance computing.
• Experience with machine learning (e.g., TensorFlow/Keras/PyTorch) will be considered an advantage.
• Experience with single-cell or spatial genomics will be considered an advantage.
• Expertise in gene regulation or comparative regulatory genomics will be considered an advantage.

Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education.

Access to state-of-the-art compute & GPU infrastructure and large state-of-the-art genomics datasets and experimental platforms.

A creative and inspiring environment, driven by curiosity and aimed at tackling fundamental biomedical problems.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.

Location: Stockholm

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A motivation letter
• A complete list of publications
• Names of three references
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.