Principal Scientist, CAR Screening and Lead Selection (CGM) Full-time

Principal Scientist, CAR Screening And Lead Selection (CGM)

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

We are searching for the best talent for a Principal Scientist, CAR Screening and Lead Selection (CGM), to be based in Cambridge, MA. Purpose: We are seeking an experienced and highly motivated Principal Scientist to join our CAR Screening and Lead Selection team focused on advancing next-generation cell therapies. The Principal Scientist will work with team leadership to develop and execute the scientific strategy to select CAR-T candidates and generate data sets that drive pipeline progression. This role offers the opportunity to work cross-functionally in a dynamic, fast-paced environment with cutting-edge technologies.

You will be responsible for:

• Advance multiple pipeline programs by designing, executing, and analyzing complex in vitro assays that stratify lead CAR-T constructs based on phenotype and function.
• Contribute to strategic project planning; integrating results and departments goals into next steps.
• Subject matter expert for specified research projects and/or laboratory techniques.
• Uses new developments and technologies to improve scientific workflows.
• Thorough analysis of complex data sets, effectively communicates impact of experimental results to leadership and key stakeholders.
• Collaborate closely with colleagues in discovery, process development, and therapeutic area teams to align priorities and share data.
• Contribute to broader team experimental designs, scientific strategy discussions and provide guidance and support to junior team members.
• Follow best practice lab operations for safety, data integrity, and reproducibility.
• Maintain meticulous records of experimental design, data, and analysis using electronic lab notebook (ELN).

Qualifications:

• PhD in immunology, cell biology, or a related field with 4+ years of relevant industry or experience; OR a Master's or Bachelor's degree with 6-8 years of experience will also be considered.
• Demonstrated experience with project planning and CAR T candidate selection.
• Takes initiative to advance scientific capabilities; challenges status quo to improve workflows and technical skillset.
• Extensive hands-on experience with multiparameter flow cytometry, including panel design, sample preparation, acquisition, and data analysis.
• Experienced with spectral flow cytometry is preferred.
• Experience with intracellular cytokine staining and cytokine arrays, such as MSD or comparable.
• Proficiency in IncuCyte-based assays or comparable real-time cytotoxicity platforms.
• Demonstrated expertise using ELN systems for experimental documentation, experience with Benchling a plus.
• Advanced skills in data analysis and presentation using GraphPad Prism, Spotfire or similar software.
• Strong problem-solving skills and the ability to independently drive projects while working collaboratively.
• Excellent written and verbal communication skills.

This role may require up to 10% travel. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center or contact AskGS to be directed to your accommodation resource.

Required Skills: Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research

Preferred Skills: Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research

The anticipated base pay range for this position is: $117,000.00 – $201,250.00

Additional Description for Pay Transparency: Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation –120 hours per calendar year Sick time – 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year Holiday pay, including Floating Holidays –13 days per calendar year Work, Personal and Family Time – up to 40 hours per calendar year Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year Caregiver Leave – 80 hours in a 52-week rolling period10 days Volunteer Leave – 32 hours per calendar year Military Spouse Time-Off – 80 hours per calendar year