Principal Scientist, Computational Pathobiologist Full-time

Principal Scientist, Computational Pathobiologist

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

The Pathobiology Department within Preclinical Sciences and Translational Safety (PSTS) is seeking an intellectually bold, highly motivated scientific leader to help shape the next generation of Computational Pathobiology.

As Principal Scientist, you will do more than support science—you will help build the digital and analytical engine that powers our science, shaping the future of translational safety. In this role, you will democratize Pathobiology data and design, build, and deploy modern data pipelines, automations, and AI-enabled analytics that transform multimodal nonclinical data into clear, decision-ready insight. You will translate complex Pathobiology questions into actionable data science challenges, applying analytics, visualization, modeling, and AI to generate mechanistically grounded adverse outcome pathways, deepen understanding of on- and off-target safety findings, and strengthen translational safety confidence across the portfolio.

You will be responsible for:

• Shape the Pathobiology Digital Transformation Vision and Strategy
• Build Scalable Data Foundations
• Deliver Insight Through Sophisticated Analytics, Visualization & AI
• Collaborate to achieve Cross-Functional Digital Delivery
• Advance Digital Pathobiology
• Serve as Technical & Scientific Leader
• Communicate Science with Impact

Qualifications / Requirements:

• Minimum of a Master's degree in a relevant scientific or computational discipline is required
• PhD is preferred
• 6+ years of proven experience applying data science/engineering and biostatistics to biomedical (human or animal) multimodal data.
• Fluency in programming languages: Python and/or R
• Experience leveraging agentic AI and generative AI to automate workflows, derive programmatic solutions, and embed biological context.
• Cloud computing and deployment experience (e.g., GCP, Azure, AWS, Snowflake, Posit Connect).
• Strong foundation in AI, Machine learning and Statistics (e.g. clustering, random forests, SVM, LLMs, regression modeling and statistical inference, integrative analysis, AlphaFold)
• Strong understanding of scientific method and hypothesis testing
• Experience developing data visualization and dashboarding tools (e.g., Spotfire, Power BI, R Shiny).

The anticipated base pay range for this position in the US is $117,000 to $201,250.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis.

Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short and long-term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).

Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:

• Vacation –120 hours per calendar year
• Sick time – 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
• Holiday pay, including Floating Holidays –13 days per calendar year
• Work, Personal and Family Time – up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave – 80 hours in a 52-week rolling period 10 days
• Volunteer Leave – 32 hours per calendar year
• Military Spouse Time-Off – 80 hours per calendar year

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.