Principal Scientist I/II, Molecular Pathology Full-time

Principal Scientist, Molecular Pathology

The Molecular Pathology team within Oncology Translational Research at Biomedical Research (BR) is seeking a highly motivated Principal Scientist to develop, validate, and scale novel approaches to characterize protein features of drug targets. This onsite role in Cambridge, MA offers the opportunity to work in a highly collaborative laboratory environment alongside cross-functional teams.

In this role, you will lead efforts to understand how protein features—including proteoforms, localization, conformation, and interactions—impact response and resistance in cancer. You will partner closely with target validation, drug discovery, and translational teams to generate insights from patient samples and translate findings to preclinical models. Your work will directly contribute to translational strategies across the drug development continuum, from target characterization through biomarker development.

Key Responsibilities

• Contribute to and help shape proteomics strategy and technology platforms in a translational research environment
• Identify and develop novel scientific and methodological opportunities based on literature and internal insights
• Design, develop, and scale methods to characterize:
• Proteoforms
• Protein localization
• Conformation
• Protein–protein interactions
• Apply approaches to patient-derived samples and define translational relevance in preclinical models
• Collaborate across matrixed teams spanning Oncology Research, Discovery, and Translational Science
• Lead or contribute to cross-functional initiatives supporting target understanding and biomarker development

Essential Requirements

• PhD in Oncology, Cell Biology, Biochemistry, Molecular Biology, or a related discipline

• Leveling criteria (dual posting):

  • Principal Scientist I: 3+ years of postdoctoral training
  • Principal Scientist II: Postdoctoral training + 3+ years of industry experience

• Proven ability to generate data that influences scientific and technical decision-making

• Experience with:

  • In vitro and in vivo models
  • Clinical or post-mortem patient samples

• Strong expertise in protein characterization techniques, including:

  • Western blotting
  • ELISA
  • FACS
  • High-content imaging
  • Microscopy-based approaches

• Experience with methods to probe, label, and enrich proteoforms or related protein features

• Strong critical thinking, communication, and collaboration skills

• Curiosity and adaptability to explore emerging technologies and scientific innovations

Desirable Qualifications

• Experience with mass spectrometry and proteomics workflows (data generation and interpretation)
• Data analysis and visualization skills (e.g., Spotfire, R)