Principal Scientist, Inflammation and Fibrosis Full-time

GSK Cell Biologist Position

GSK, with bold ambitions for patients, aims to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. We're uniting science, technology, and talent to get ahead of disease together.

We are seeking a highly motivated, enthusiastic and skilled cell biologist to join our group within the Human Biology department at our US Research Hub. This laboratory-based role is critical to advancing our early discovery efforts through the development and application of physiologically relevant in vitro models that mimic complex disease biology. The successful candidate will leverage cutting-edge technologies, including primary human cells, phenotypic profiling, gene editing, and functional genomics, to drive target discovery and validation efforts in areas of high unmet medical need. Working in a multidisciplinary and collaborative environment, you will generate impactful insights that inform and accelerate therapeutic discovery and development.

Responsibilities include:

This role will provide you the opportunity to lead key activities to progress your career. These responsibilities include some of the following:

• Laboratory-based role
• Lead the design and execution of experiments involving primary human cells and advanced in vitro systems to support early target discovery, validation and mechanistic studies.
• Develop and apply complex cellular models (e.g., co-culture, 3D systems) to better recapitulate human disease biology (e.g. autoimmune, fibrosis).
• Apply CRISPR-based gene editing, molecular biology, automation, and high-dimensional flow cytometry techniques to interrogate gene function in disease contexts.
• Translate biological insights into clinically actionable therapeutic strategies, aligned with disease-relevant endpoints.
• Collaborate cross-functionally with internal and external partners in human genetics, computational biology, AI/ML, automation, and disease areas.
• Maintain excellent experimental records according to GSK compliance.
• Communicate experimental findings effectively (in written and verbal formats) in internal and external scientific forums

Our values and expectations: We look for team members who act with patient focus, transparency, respect, and integrity. You will be expected to operate at pace, use evidence to make thoughtful decisions, and deliver high quality results. We value learning, collaboration, and well-being. We welcome candidates who bring different perspectives and life experiences.