Principal Scientist-Process Development Full-time

Peptide Chemist

We are seeking a highly motivated Peptide Chemist with deep expertise in enzymatic peptide synthesis and biocatalysis to contribute to the discovery and development of innovative processes for peptide and API manufacturing. The successful candidate will independently design and execute cutting-edge enzymatic strategies, collaborate cross-functionally across R&D and manufacturing organizations, and contribute to the advancement of scalable, sustainable synthetic technologies. A PhD in chemistry, chemical biology, biocatalysis, biochemical engineering, or related discipline is required; industry experience is strongly preferred. This role offers the opportunity to work at the interface of biocatalysis, peptide chemistry, and process innovation, with access to cutting-edge enzymatic and analytical technologies. The successful candidate will contribute directly to the development of next-generation peptide and API processes that support clinical and commercial manufacturing.

Role Responsibilities

• Enzymatic Platform and Process Development
• Experimental Execution & Documentation
• Scientific Innovation & Strategy
• Collaboration & Cross-Functional Integration
• Leadership & Talent Development
• Reporting & Scientific Communication

Required Education/Experience (Minimum Requirements)

• PhD in Organic Chemistry, Biochemistry, Chemical Biology, Biocatalysis, Enzymology, Biochemical Engineering, or a closely related discipline, with minimum of 4+ years of relevant experience
• Demonstrated expertise in enzymatic reactions, biocatalysis and enzyme enabled peptide synthesis.
• Strong experimental skills, including reaction optimization, data interpretation, and troubleshooting.
• Experience with enzyme screening, reaction scale up, and process-oriented thinking.

Desirable Technical Skills (Preferred Requirements)

• Industry experience in pharmaceuticals, biotech, or chemical process development.
• Hands on experience with peptide synthesis (solution phase, solid phase, chemoenzymatic methods).
• Familiarity with enzyme engineering tools or directed evolution approaches.
• Understanding of process chemistry constraints (e.g., green chemistry, robustness, scalability).
• Strong communication, documentation, and interpersonal skills.
• Demonstrated ability to collaborate effectively across multidisciplinary teams.

Physical/Mental Requirements

• Ability to work in a standard laboratory environment, including performing experiments at the bench and in laboratory fume hoods; ability to handle chemicals, enzymes, and analytical equipment following all safety protocols.
• High level of self-awareness, demonstrating openness to feedback and proactively seeking input from others to improve ideas, troubleshoot challenges, and enhance scientific outcomes.
• Adaptability and change agility, with the ability to quickly reprioritize, adjust approaches, and respond to changes in project direction or scientific strategy.

Non-Standard Work Schedule, Travel or Environment Requirements

• Occasional domestic and international travel (0–5%) may be required to support technology development, clinical manufacturing activities, and technology transfer to commercial manufacturing sites.
• Travel may involve short visits to partner R&D laboratories, pilot-plant facilities, or manufacturing locations to facilitate collaboration, troubleshooting, or implementation of enzymatic processes.
• Flexibility to accommodate shifting project priorities and timelines as development needs evolve.

Relocation assistance may be available based on business needs and/or eligibility.