Research Fellow in Brain Vascular Biology and Brain Cancer Biology Full-time

Research Fellow in Brain Vascular Biology and Brain Cancer Biology

The Group of Brain Vasculature and Perivascular Niche focuses on vascular growth and the development of blood vessels (angiogenesis) in the brain, including endothelial cells and perivascular cells of the neurovascular unit/perivascular niche, and on brain vascular heterogeneity in development, health and disease: The main aims are: i) to understand the cellular and molecular underpinnings that govern the growth of the developing, adult, and diseased human brain vasculature at single-cell resolution, ii) to uncover the single-cell transcriptomic, genomic and epigenomic landscapes and spatial biology of the developing, adult and diseased human brain vasculature, iii) to elucidate how developmental programs regulate vascular growth/angiogenesis in the human brain tumour vasculature (patho-fetal axis / onco-fetal axis), iv) to unravel the onco-fetal programs of vascular growth/angiogenesis and immunosuppression/immunomodulation, and v) to translate these fundamental insights about the onco-fetal axis in the human brain (tumour) vasculature into clinical settings with the ultimate goal to identify novel therapeutic strategies for human brain tumours (and for other vascular-dependent diseases such as human brain vascular malformations).

The role will be available for one year in the first instance with the possibility of extension. Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B, with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.

Applications should include a CV and a Cover Letter: In the Cover Letter please provide evidence of the essential and desirable criteria in the Person Specification part of the Job Description. (By including a Cover Letter, you can leave blank the 'Why you have applied for this role' field in the application form, which is limited in the number of characters it will allow.)