Research Fellow (Single-molecule biophysics) Full-time

Research Fellow Position

The Institute for Digital Molecular Analytics and Science (IDMxS) is seeking a highly motivated and creative Research Fellow to join our team and lead an exciting project on how biomolecular condensates regulate enzyme function. We use quantitative single-molecule approaches to link enzyme structure, dynamics, and kinetics in both condensate and dilute environments. By integrating complementary measurements across timescales, we investigate conformational state switching, reaction dynamics under non-equilibrium conditions, and molecular mobility and permeability within dense phases.

Responsibilities:

• Research Leadership: Spearhead an independent project decoding how biomolecular condensates regulate enzyme function.
• Tool Engineering: Design and validate novel molecular probes or synthetic condensates, leveraging genetic engineering or generative protein design.
• Data acquisition: Apply advanced single-molecule spectroscopy methods to measure molecular dynamics in vitro and in cell.
• Output: Drive the publication (scientific papers and conference presentations) of high-impact findings.

Requirements:

• PhD in biophysics, biochemistry, molecular biology, cell biology, or a closely related field
• Strong track record of experimentation and quantitative thinking
• Demonstrated ability to analyze complex datasets and communicate results clearly (talks, manuscripts)
• Strong motivation, reliability, and ability to work both independently and with a team
• Experience with single‑molecule spectroscopy techniques (e.g. smFRET, FCS)
• Expertise in protein/DNA biochemistry, including labelling strategies, expression, purification, activity assays, and reconstitution
• Data analysis skills are advantageous, particularly experience with MATLAB, Mathematica, or similar platforms
• Experience in live‑cell imaging is helpful but not required
• Experience with microfluidics (e.g. device operation, rapid mixing, or reaction control); fabrication experience is an advantage but not required

We regret to inform that only shortlisted candidates will be notified.

Hiring Institution: NTU