Research Scientist (SXY Lab), IMCB Full-time

Research Scientist (SXY Lab), IMCB

The Translational Retinal Research Laboratory is looking for a passionate and driven Scientist to advance our cutting-edge work in Nucleic Acid therapeutics for retinal diseases. This role offers a unique opportunity to work at the intersection of stem cell biology, gene regulation, and translational medicine, developing and testing next-generation therapeutics for Age-related Macular Degeneration (AMD).

Responsibilities:

• Develop and apply human stem cell-derived retinal epithelial and endothelial cells for therapeutic screening.
• Evaluate therapeutic uptake, trafficking, and knockdown efficiency using advanced molecular and cellular assays.
• Build and apply functional assays (e.g. migration, tube formation) to assess therapeutic outcomes.
• Test lead candidates in preclinical mouse models, evaluating biodistribution and efficacy through various delivery routes.
• Collaborate with a dynamic, multidisciplinary team, contributing to publications, presentations, and translational milestones.
• Drive reporting outputs including progress updates, invention disclosures, and final research reports.

Job requirements:

• PhD in Biology, Biomedical Science, Biotechnology, or related field (or equivalent experience).
• Strong background in stem cell biology, with experience in epithelial or vascular endothelial differentiation is preferred.
• Expertise in cellular and molecular techniques (e.g. qPCR, immunofluorescence, confocal microscopy, flow cytometry).
• Experience in in-vitro and in-vivo (rodent) disease modelling is highly preferred.
• Proven ability to design, execute, and analyze complex experiments with attention to detail.
• Strong communication skills and a collaborative mindset, with a track record of scientific writing or high impact publication.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Type of Employment: Full-Time

Work Location: Biopolis