Research Senior Scientist, Biochemical Lead Profiling Full-time

Research Scientist

Takeda's Lead Profiling team is building a new team of experienced, innovative, and collaborative researchers to partner with Drug Discovery Units to design and run high throughput automated assays on state-of-the-art robotic platforms to drive an industry-leading portfolio of drugs for various therapeutic areas with high unmet medical needs. We are seeking a skilled Research Scientist to join our Lead Profiling and cross-functional discovery teams.

Design and execute pre-clinical pharmacology assays on fully automated robotic platforms to support candidate selection, accelerating clinical translation of impactful therapies for patients with various disorders.

Provide deep scientific expertise in the design and execution of miniaturized, high throughput assays to support programs across cross-functional teams.

Leverage state-of-the-art automation to streamline complex biology screening workflows and manage data across various programs, in close collaboration with Takeda scientists and external partners.

Lead high throughput, fully automated, pharmacology studies to enable advancement of drug candidates into early clinical trials.

Design and execute pre-clinical pharmacology assays on fully automated robotic platforms to support candidate selection, accelerating clinical translation of impactful therapies for patients with various disorders.

Champion scientific integrity and rigor in data analysis, preparation, and interpretation of detailed protocols/SOPs.

Collaborate cross-functionally with Automation Engineers, Scientists and Data Science teams to support data-driven decision-making.

Proactively leverage state-of-the-art automation to streamline complex assay workflows and generate data to support various programs, in close collaboration with Takeda scientists and external partners.

Expected: PhD degree in Biochemistry, Biophysics, Pharmacology, Molecular/Cell Biology or related field or MS with 6+ years of experience, or BS with 8+ years of relevant experience in pharmaceutical/biotech R&D.

Experience with fully integrated automation platforms and assay miniaturization, as well as high throughput data analysis systems.

Good expertise is Lead ID, Hit-to-Lead and Lead Op strategies and workflows is highly desirable.

Significant experience leveraging high throughput data analysis platforms and LIMS systems for automated data analysis, QC and reporting.

Proven expertise in design and development of biochemical 384 and 1536-well plate-based assays (e.g., fluorescence, HTRF, FRET, bioluminescence assays, BRET etc.)

Demonstrated ability to work independently and collaboratively to advance drug discovery projects in a highly matrixed environment.

Excellent communication, organizational, and multitasking skills.

The position will be based in Cambridge, MA.

U.S. Base Salary Range: $111,800.00 – $175,670.00

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