Scientist Biopharmaceutics (in vitro/in silico) Full-time NEW

Biopharmaceutics In Vitro/In Silico Scientist

Johnson & Johnson Innovative Medicine develops innovative, effective treatments across four therapeutic areas with high unmet medical need: oncology, immunology, neuroscience, and cardiopulmonary diseases. The Janssen campus in Beerse, near Antwerp, Belgium, offers a unique ecosystem spanning the full drug development life cycle, with capabilities ranging from basic science to market access on a single campus.

The biopharmaceutics group is part of Pharmaceutical & Material Sciences in Pharmaceutical Product Development & Supply, and cooperates closely with the High Throughput and Preformulation Sciences (HTPS) group to perform all in vitro work. Both groups support the drug product design process for synthetic molecules (including oral peptides) by characterizing and optimizing the relationship between active ingredient properties, drug product performance, and in vivo behavior.

You will be responsible for:

• Design and execution of in vitro experiments, including standard and customized solubility, precipitation, and dissolution testing, to support biopharmaceutical profiling for development projects in the synthetic molecule portfolio, with a focus on oral peptides.
• Applying in silico absorption modeling, such as physiology based biopharmaceutics and/or pharmacokinetic modeling, to characterize the interface between drug product performance and physiological conditions, and to predict absorption and permeation (incl oral peptides).
• Working at the interface between Biopharmaceutics and High Throughput Preformulation Sciences, and integrate all in vitro and in silico data to assess, predict and improve the absorption of oral synthetic molecules including peptides.
• Collaborating proactively with external partners, including academic institutions and private research organizations, to stay current with emerging scientific, industrial, and regulatory developments in biopharmaceutics across in vitro and in silico approaches.
• Driving innovation of integrated in vitro / in silico workflows to accelerate biopharmaceutical understanding and rational formulation design/selection Building strong partnerships with key stakeholders, including Discovery Sciences, Preclinical DMPK, Non-Clinical Safety, Clinical Pharmacology, Regulatory Affairs, API Development, Drug Product Development, and Analytical Development.

Qualifications / Requirements:

• Masters or Doctoral degree (Ph.D.) in Pharmaceutical Sciences, Chemistry, Biology, Engineering, or a related scientific field, with preferably more than two years of relevant industrial experience in biopharmaceutics including preformulation aspects and computational modeling, preferably in drug absorption and disposition.
• Knowledge of some of the following areas is preferred: physico-chemical characterisation, drug absorption and disposition, formulation development and design for oral peptides, and pharmacokinetics.
• Proven ability to contribute as an independent scientific specialist, with excellent interpersonal, communication, and collaboration skills, and a strong sense of personal accountability.

The anticipated base pay range for this position is: €60,000.00 – €96,255.00

In addition to base pay, we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees' and companies' performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees – and in some location's eligible dependents – can participate in several insurance plans. For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.