Scientist, Bioscience Immunology Full-time

Scientist, Bioscience Immunology

Are you driven to transform cutting-edge immunology into therapies that make a tangible difference for patients? Do you thrive in fast-moving scientific environments where not all the answers are known yet? Join a lab-based team in Waltham, MA, dedicated to discovering, validating, and advancing novel targets using human in vitro systems and primary and disease tissue-derived cells.

In this role, you will connect deep biological insight to decision-making in drug discovery. Working in state-of-the-art labs alongside accomplished scientists, you will characterize immune pathways in health and disease, design and optimize assays, and generate data that shape program strategy. Expect high visibility, cross-functional collaboration, and the opportunity to publish impactful work while building capabilities that accelerate medicines to patients.

Accountabilities

• Immunology Pathway Characterization: Define and interrogate novel immunological pathways in health and disease to drive target validation and guide therapeutic hypotheses for drug projects.
• Human In Vitro and Ex Vivo Models: Design, execute, and refine studies using primary and disease tissue-derived cells to generate translational data that inform program decisions.
• Assay Development and Validation: Build, optimize, and qualify robust cellular, molecular, and protein assays; establish standards and controls to ensure reproducibility and decision-grade data.
• Advanced Analytics and Data Integrity: Apply rigorous experimental design and statistical thinking to critically analyze complex datasets and communicate clear, actionable conclusions.
• Cross-Functional Collaboration: Partner with project teams and external collaborators to align on goals, share insights, and accelerate progress; bring external science and technologies in when they create advantage.
• Scientific Leadership and Publication: Lead aspects of the biology, contribute to strategy discussions, and publish high-quality research in reputable journals to advance the field and our pipeline.
• Continuous Improvement in a Dynamic Environment: Navigate ambiguity with resilience; iterate quickly, learn from setbacks, and adopt inventive approaches that keep programs moving at pace.

Essential Skills/Experience

• Bachelor's degree in biology, immunology or relevant discipline with 5+ years of relevant industry experience, Master's degree in biology, immunology or relevant discipline with 3+ years of relevant industry experience, or PhD degree in biology, immunology or relevant discipline with 0+ years of post-doctoral experience is required
• Expertise in adaptive and innate immunity, primary cell culture and assay development is essential
• Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team to conduct a high-level research project is essential
• Strong hands-on skills in basic biochemical and molecular techniques, with proficiency in at least several of the following: primary cell culture, quantification of mRNA (qPCR), multi-panel flow cytometry (including both intracellular and extracellular markers), protein expression; ELISA, Western blot, MSD, Luminex
• Strong written and oral communication skills and the ability to critically analyze data sets
• Demonstrated ability to run collaborative efforts and utilize external resources to find the most effective solutions

Desirable Skills/Experience

• Previous experience in antigen-specific immune responses, TCR discovery or immune tolerance
• Experience with multiplex cytokine read-outs and in vitro/ex vivo culture of immune cells
• Knowledge and experience of in vivo science

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca

Here, curiosity meets purpose. You will join a community that pushes boundaries with the latest science and technology, values kindness alongside ambition, and learns openly from critique to get to better solutions. We bring different disciplines together around the bench, move quickly through uncertainty, and take smart risks to speed new medicines to patients worldwide. Your ideas and data will be seen, tested and acted on, giving you the platform to grow while contributing to research that delivers clear, tangible impact for society.

If you are ready to turn bold immunology into real-world medicines, step into our Waltham labs and help shape what comes next—send your CV and make your move today.

The annual base pay for this position ranges from $92,252 to $138,378. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.