Scientist, Cardiac Vascular – In Vivo Full-time

Cardiac And Vascular Rodent Surgeon

Build our future together: At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Cardiac and Vascular Rodent Surgeon to join our cardiovascular research team, serving as a key contributor to the design and execution of longitudinal in-vivo rodent studies supporting our cardiovascular disease programs. In this role, you will perform advanced surgical models of cardiac disease, conduct precision dosing and physiological monitoring, and generate high-quality functional and molecular data to support target validation and therapeutic development.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & where:

• Location: Tarrytown, NY
• Work model/flexibility: Onsite

Discover your role:

• Perform surgical models of cardiac and vascular disease in mice and rats, including transverse aortic constriction (TAC), myocardial infarction (MI), and renal/kidney models (RKM)
• Administer test articles via multiple routes (IV, SC, IM) or osmotic minipump implantation with precision and consistency across longitudinal study timelines
• Implant and manage telemetry devices for continuous blood pressure and ECG monitoring in conscious, freely moving rodents
• Conduct invasive hemodynamic assessments using PV-loop methodology to quantify cardiac function
• Perform ex-vivo tissue collection and processing, including cardiac dissociation via Langendorff perfusion
• Manage end-to-end in-vivo study logistics, including animal health monitoring, surgical scheduling, and post-operative care
• Analyze and interpret physiological, hemodynamic, and functional data using PRISM, PONEMAH, and other relevant analysis software
• Generate high-quality figures, reports, and data summaries for internal presentations, regulatory packages, and peer-reviewed publications
• Maintain rigorous records of surgical procedures, animal welfare documentation, and study protocols in compliance with institutional and regulatory standards
• Collaborate closely with study directors, therapeutic area scientists, and cross-functional teams to align surgical and analytical approaches with program goals
• Proactively flag capacity constraints, scheduling conflicts, or technical challenges to stakeholders

This role requires:

• BS with 10+ years, MS with 6+ years with relevant experience in a related field (e.g., Physiology, Biomedical Sciences, Veterinary Science, or similar)
• Demonstrated hands-on expertise in rodent cardiac and vascular surgical models (TAC, MI, RKM)
• Proficiency in rodent dosing techniques (IV, SC, IM) and telemetry implantation for blood pressure and ECG monitoring
• Experience with invasive hemodynamic measurement techniques, including PV-loop analysis
• Hands-on experience with Langendorff perfusion and cardiac tissue dissociation
• Proficiency with data analysis software such as PRISM and PONEMAH
• Strong understanding of rodent anatomy, physiology, and survival surgery best practices
• Excellent organizational skills, with the ability to manage multiple longitudinal studies and competing priorities simultaneously
• Strong attention to detail and commitment to scientific rigor and animal welfare standards
• Excellent oral and written communication skills
• Preferred: experience with additional cardiovascular functional assessment techniques or prior work in a GLP/regulated research environment