Scientist I, Biopharmaceutics Full-time

AbbVie Scientist I

AbbVie's Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. MPDD scientists utilize state-of-the-art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaboratively progress candidates with higher probability of success into development and advise clinical formulation strategy.

AbbVie's MPDD organization is seeking a highly motivated scientist with experience in biopharmaceutics for a Scientist I position. The primary role of this position is to design, execute, analyze, and interpret the studies that characterize the biopharmaceutical properties of drug candidates and enable developability and product performance related informed decision-making for emerging molecules on peptide and small molecule pipeline programs.

Key Responsibilities:

• Design, execute, troubleshoot, and interpret experiments related to biopharmaceutics properties of small molecules and peptides such as solubility, dissolution, permeability, stability, aggregation, precipitation, and formulation performance, as applicable.
• Generate high-quality data and maintain accurate, timely, and complete documentation of experimental procedures, results, and conclusions.
• Analyze and summarize data using appropriate scientific methods and communicate findings to project teams and functional stakeholders.
• Contribute to the assessment of candidate molecules and formulations by identifying key risks, opportunities, and data-driven recommendations.
• Support development, optimization, and continuous improvement of experimental methods, workflows, and scientific capabilities.
• Maintain awareness of external scientific advances and incorporate relevant knowledge into project work where appropriate.

Qualifications:

• Bachelor's Degree or equivalent education with typically 5 years of experience, or master's degree or equivalent education with typically two years of experience in pharmaceutical or related industry. Preferred educational backgrounds include but are not restricted to Pharmaceutical Sciences, Pharmaceutical Engineering, Chemical/ Biomedical Engineering, Chemistry, and Materials Science.
• Fundamental understanding of biopharmaceutics in relation to drug absorption across routes of administration including solubility, biorelevant dissolution testing, permeability, ex vivo permeability assessment, and peptide aggregation.
• Familiarity and preferred hands-on laboratory experience in in vitro assays and standard analytical techniques for physicochemical and biopharmaceutical property assessment to understand CMC developability profile. Techniques of interest include, but are not limited to chromatography, DSF, rat intestinal perfusion, Ussing Chambers, Franz Diffusion cells, dissolution, X-ray diffraction, thermal analysis, microscopy, biophysical characterization techniques, etc.
• Knowledge of preclinical and clinical formulation development principles relevant to chemically synthesized molecules across routes of administration.
• Ability to analyze data and draw scientifically sound conclusions.
• Demonstrated strong communication skills and ability to clearly communicate theories and concepts, influence others without authority, and drive technical excellence.
• Excellent self-management skills, organizational skills, and attention to detail.

Key Leadership Competencies:

• Builds strong relationship with peers and cross-functional partners to enable higher performance.
• Learns fast, grasps the “essence”, and can change course quickly where indicated.
• Connects ideas from disparate fields, integrates data and information quickly, and takes risks to achieve the highest performance.
• Raises the bar and is never satisfied with the status quo. Demonstrates scientific curiosity and problem-solving ability.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Pay Range: $75000 – 142500 USD