Scientist – In Vivo Full-time

Associate Scientist, Cardiometabolic Disease

Our company's South San Francisco research laboratory is seeking an innovative drug hunter with a strong in vivo background in biology or metabolism to join the cardiometabolic disease department. The individual will perform experiments in the laboratory with minimal guidance and supervision. The successful candidate will design, execute, and interpret complex in vivo/ex vivo/in vitro studies to support target identification, validation, and therapeutic development. The successful candidate will also possess a strong sense of intellectual curiosity to expand their technical expertise at the bench, as well as effective written and interpersonal communication skills to explain complex experiments and biological concepts to a broader scientific team.

Key Responsibilities:

• Establish key assays and model systems, suitable for the mechanistic investigation of potential targets, as well as evaluation of therapeutic candidates.
• In vivo dosing, bleeding, and handling of small laboratory animals
• Perform molecular biology, cellular biology, cell-based assay, and ex vivo sample processing and analysis.
• Design, perform, troubleshoot, document, analyze and interpret assigned research, with minimal supervision, to support exploratory activities as well as project focused goals.
• Scour and critically evaluate current literature to identify opportunities for new and existing programs.
• Work independently in executing tightly controlled experiments, analyzing data, and presenting to teams within the disease area.
• Solve complex problems by undertaking innovative approaches and applying state-of-the art technologies.

NOTE: This role will be required to work on weekends in a shifted work-week schedule (Tuesday – Saturday / Sunday – Thursday)

Qualifications:

Education:

• Bachelor's (with 3+ years) or Master's in chemical biology, molecular and cellular biology, pharmacology, biology or other related scientific discipline and relevant experience.

Required Experience and Skills:

• Experience in one or more of the following areas: target validation, in-vivo model development or adipose biology.
• Experience with handling, dosing (oral, subcutaneous, intraperitoneal, intravenous), and bleeding small laboratory animals.
• Experience working with human as well as pre-clinical tissues and primary cell lines.
• Experience with standard molecular biology techniques (western blotting, qPCR, etc).
• Works independently and is able to simultaneously handle a varied workload with strong organizational and time management skills.
• Strong communication and interpersonal skills as well as the ability to work flexibly in a dynamic team environment.
• Scientific curiosity, analytical mindset with a drive to own a project to understand biology, mechanism of action, and drive it through the discovery pipeline.

Preferred Experience and Skills:

• Prior industry experience
• Experience in target identification, muscle biology or immunology in the context of metabolic disease

Required Skills:

Cell Biology, Cell Cultures, Cell Culture Techniques, Dosing, In Vivo Models, In Vivo Studies, Molecular Biology Techniques, Primary Cells, Target Validation

Preferred Skills: