Scientist, Oligonucleotide Sciences Analytical Chemistry Full-time

Scientist, Oligonucleotide Discovery Analytical Chemistry

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

Works on separation, identification and quantification of chemical components of natural and synthetic materials. Designs and performs quantitative and/or qualitative analysis using classical and instrumental methods.

Are you looking for a collaborative analytical chemistry role that allows you to meaningfully contribute GSK's pre-clinical oligonucleotide pipeline? If so, this role could be an ideal opportunity to explore.

As Scientist, Oligonucleotide Discovery Analytical Chemistry, you and your team will play an important role in the analysis and quality control of GSK's preclinical oligonucleotide therapeutics pipeline. You will execute and develop advanced analytical methods for a diversity of synthetic oligonucleotide modalities to help accelerate GSK's pipeline and platform technology ambitions.

This role will provide you the opportunity to lead key activities to progress your career. These responsibilities include some of the following:

• Operate and execute validated analytical methods to enable the high-throughput oligonucleotide production platform.
• Develop and deploy robust analytical methods to support in-house oligonucleotide synthesis, including novel chemistries and conjugates.
• Use advanced analytical technologies to fully characterize novel synthetic oligonucleotides and related species in low-and high-throughput settings.
• Collaborate internally and externally, representing Oligonucleotide Discovery Analytical Chemistry on project teams.
• Support analytical investigations, including root cause analysis, in collaboration with cross-functional teams.

Why You? Basic Qualification We are seeking professionals with the following required skills and qualifications to help us achieve our goals:

• A BS degree with at least 5 years of relevant experience or an MS degree with at least 4 years of relevant experience in analytical chemistry or a related discipline (or equivalent).
• At least one year of experience using LC/MS(-MS) methodology in a biotechnology, pharmaceutical, or academic setting.
• At least one year of experience performing mass spectrometry data analysis
• Demonstrable exposure to LC/MS(-MS) method development and method troubleshooting.

Preferred Qualification If you have the following characteristics, it would be a plus:

• Professional experience in the field of oligonucleotide therapeutics.
• Experience with high-resolution LC/MS(-MS) data acquisition and analysis.
• Experience with high-throughput LC/MS(-MS) methodology.
• Experience using reverse phase/ion-pairing, anion exchange, size-exclusion, and/or hydrophilic interaction chromatography.
• Experience with other analytical methodology, such as NMR, X-ray crystallography, UV/Vis spectrophotometry, or circular dichroism.
• Exposure to other aspects of drug discovery & development, including in vitro biology, bioanalysis, DMPK, delivery, etc.
• Excellent communication, presentation, and documentation skills.
• Familiarity working in cross-functional matrix project teams.

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

• Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigor and risk.
• Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
• Continuously looking for opportunities to learn, build skills and share learning
• Sustaining energy and well-being.
• Building strong relationships and collaboration, honest and open conversations.
• Budgeting and cost-consciousness.

How to apply If you are excited about advancing oligonucleotide analytics and making a real impact on our work to get ahead of disease together, we would love to hear from you. Please submit your CV and a short cover letter describing your most relevant analytical experience and why this role matters to you.