Scientist, Pharmacokinetics Full-time

Biologics Drug Discovery Scientist

This position will support our Company's biologics drug discovery and development efforts in the Drug Metabolism and Pharmacokinetics (DMPK) Group within the Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) organization at our Research & Development Division in South San Francisco.

The successful candidate will be a laboratory‑based scientist responsible for generating in vitro and in vivo ADME and pharmacokinetic data to support biologics programs. The role applies strong foundational expertise in protein biochemistry and biophysics to understand how molecular properties influence clearance mechanisms and PK/PD relationships of biologics including antibodies, bi‑/multi‑specifics, peptides, conjugates, and other novel modalities.

We are seeking a flexible, curious, and proactive scientist with strong protein biochemistry/biophysics expertise and a passion for both reliably executing routine, decision‑enabling assays and developing and optimizing new assays that support biologics programs across multiple therapeutic areas. In this role, the scientist will have the opportunity to work closely with project teams and partner groups across our network to advance drug discovery efforts. Candidates who are enthusiastic about supporting pipeline needs through high‑quality, reproducible assay execution, motivated to investigate mechanistic drivers of protein interactions, and interested in automation and biophysical techniques are especially encouraged to apply.

Key Responsibilities:

• Perform routine and exploratory biochemistry and biophysics‑based assays, including protein biochemistry and biophysical interaction assays to quantify receptor binding, cellular trafficking and degradation, non-specific binding/clearance and other DMPK properties of biologics.
• Partner with cross-functional teams to design, optimize, and execute assays aligned with project needs
• Generate and analyze data with high attention to detail, and maintain complete and accurate electronic laboratory notebooks
• Contribute to the implementation of automation solutions and semi-automated workflows to increase throughput and reproducibility
• Support the development and optimization of protocols and standard operating procedures and maintain and troubleshoot instruments
• Communicate experimental plans and results clearly via written reports and verbal presentations

Qualifications:

Education:

• Bachelor's (with 3+ years) or Master's in biochemistry, biophysics, biotechnology, bioengineering, pharmacology or a related scientific discipline and relevant laboratory experience​

Required Experience and Skills:

• Strong foundation in protein biophysics/biochemistry principles, with the ability to apply these concepts in a biological or translational context (eg., protein interactions, binding kinetics, intracellular trafficking, in vivo clearance)
• Hands-on experience with biochemical/biophysical techniques to characterize proteins (e.g., immunoprecipitation, flow cytometry, mass spectrometry, SPR/BLI, meso scale discovery, fluorescence spectroscopy, NMR/ HDX/MS)
• Ability to analyze, troubleshoot, organize, and interpret data, with familiarity using software such as GraphPad Prism, Excel, or similar tools
• Excellent attention to detail, strong documentation practices, and the ability to work in a fast-paced research environment
• Strong interpersonal, problem-solving, and communication skills with a collaborative and growth-oriented mindset

Preferred Experience and Skills:

• Experience with biologics DMPK assays, such as receptor binding kinetics, drug/receptor internalization, and cellular trafficking assays
• Experience in cell culture and execution of cell‑based functional assays
• Experience quantifying protein concentrations in biological matrices using ligand-binding assays (e.g., ELISA, meso scale discovery, etc.)
• Prior experience with Octet/BLI, SPR, or similar biophysical techniques
• Exposure to automation, liquid handlers, or high-throughput assay systems

Required Skills:

Biochemistry, Biophysics, Flow Cytometry, Fluorescence Spectrometer, Intracellular Trafficking, Kinetic Studies, Mass Spectrometry (MS), Molecular Biophysics, Protein Interactions

Preferred Skills: