Scientist, Purification, RNA Process Development Full-time NEW

Scientist, Purification, RNA Process Development

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Position Summary

The RNA Purification Process Development function plays a central role in designing efficient, robust, and scalable manufacturing processes. By combining deep scientific expertise with enabling technologies and strong cross-functional partnerships, RNA Process Development delivers transformative innovation across the pipeline.

The Scientist executes robust experiments for drug substance programs spanning early- to late-stage development across circular and linear mRNA modalities. Reporting to the Principal Scientist, this role encompasses hands-on contributions, addressing critical challenges by driving sound experimental execution and manufacturing support. The candidate should be driven by developing and characterizing chromatography and filtration steps for improving the yield, quality and robustness of purification process steps.

Key Responsibilities

• Design, execute, and analyze experiments for existing and novel process modes using DoE and statistical modeling
• Define the RNA drug substance purification process, the critical parameters, and the design space
• Experiment using high throughput/automated or data rich experimental setups
• Design experiments to confirm robust process performance across the control space
• Collaborate with analytical teams to enable deeper characterization of RNA properties and impurity profiles
• Collaborate closely with upstream PD to characterize IVT feed stream to maximize RNA yield and purity
• Prepare technical reports, and communicate findings internally and externally as appropriate
• Participate in tech transfer activities to GMP manufacturing sites for RNA programs

Qualifications & Experience

• Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field
• BS with 6+ years' experience in science related disciplines
• MS with 4-6 years' experience in science related disciplines
• PhD with 0 – 2 years' experience in science related disciplines
• Expertise in chromatography, filtration (TFF/UF-DF), and innovative separation unit operations
• Solid knowledge foundation of statistical design of experiments (DoE) and analysis of multivariate data
• Experience with performing process analytics and biophysical characterization techniques such as HPLC, CE, & gel electrophoresis
• Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing
• Demonstrated background of providing technical support for clinical manufacturing processes, including support of process investigations, and implementation of proactive process modifications
• Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus
• Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn't perfectly match your resume, we encourage you to apply anyway.