Senior Associate Scientist, Analytical Development Full-time

Senior Associate Scientist, Analytical Development

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

BMS at Kendall Square is seeking a highly skilled and motivated Senior Associate Scientist with strong expertise in analytical method development to support the advancement of novel RNA therapeutics. The successful candidate will leverage biophysical and separation techniques to design, develop, and execute analytical methods that enable comprehensive characterization of lipids, antibodies, and RNA-based modalities across discovery and development stages. This role will play a critical part in generating high-quality analytical data to support product understanding, process development, and CMC strategies.

Responsibilities:

• Independently design, develop, and optimize analytical methods to characterize RNA-based therapeutics, lipid nanoparticles, and related components.
• Support routine and platform analytical testing across safety, identity, content, purity/impurity, potency, and general quality attributes for LNP-encapsulated RNA.
• Lead phase-appropriate method lifecycle activities, including method development, qualification, validation, and transfer to internal and external laboratories (e.g., CROs/CDMOs), with authorship of SOPs, protocols, and technical reports.
• Collaborate cross-functionally with process development, formulation, research, and manufacturing teams to support analytical development, troubleshoot issues, and enable program milestones and timelines.
• Troubleshoot complex analytical challenges, interpret data, and provide scientifically sound recommendations to resolve issues and improve assay performance and robustness.
• Perform and oversee routine and non-routine analytical testing, including data review, verification, and interpretation to ensure data quality, integrity, and compliance with internal standards.
• Operate, maintain, and troubleshoot analytical instrumentation.
• Analyze and communicate complex analytical data, generating clear, concise reports and presentations to inform technical teams and leadership decisions.

Qualifications:

• B.S./M.S. in Analytical Chemistry, Biochemistry, or a related discipline with 2+ years of relevant CMC-related experience. PhD candidates with appropriate experience will be considered for this position.
• Hands-on experience with HPLC/UHPLC (IP-RP, RP, CAD detection) for RNA, lipid, and impurity quantitation.
• Hands-on experience with biophysical/biochemical characterization techniques: DLS, RiboGreen, ELISA, Raman spectroscopy, light/confocal microscopy, UV-Vis spectrophotometry
• Ability to manage multiple projects and priorities in a fast-paced environment
• Strong technical writing skills for reports, protocols, and regulatory documentation
• Familiarity with regulatory expectations (e.g., ICH, FDA) for analytical data and submissions

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn't perfectly match your resume, we encourage you to apply anyway.