Senior Associate Scientist, Chemistry Full-time

Senior Associate Scientist II, Chemistry

RayzeBio is a dynamic biotechnology company headquartered in San Diego, California, United States. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival for people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

RayzeBio is looking for a Senior Associate Scientist II, to support in the development of novel therapeutics in preclinical stages. Candidates will work as part of a team of scientists to synthesize and design both small molecules and peptide analogs to optimize potency, pharmacokinetics, and in vivo efficacy of potential drug candidates. This position offers a challenging and rewarding work environment within a thriving company.

Job Responsibilities:

• Executing multi-step synthetic routes, optimizing reaction conditions, isolation, and characterization of organic compounds (chromatography, NMR, MS, IR spectroscopy).
• Collaborating effectively with colleagues across diverse disciplines.
• Documenting research activities and presenting findings clearly.
• Execute experimental plans, troubleshoot synthetic challenges and contribute to the optimization of lead compounds.

Education and Experience:

• BS or MS in Chemistry or related field with strong understanding of organic and analytical chemistry.
• 5+ years' experience in an organic synthesis, chemistry, or analytical laboratory preferred.

Skills and Qualifications:

• Strong synthetic skills and knowledge of lab techniques.
• Proficiency in compound synthesis techniques, compound purification, and characterization methods such as LCMS, HPLC and NMR.
• Familiarity with scientific software such as ChemDraw, Scifinder, and Reaxys.
• Adaptable and flexible, able to handle multiple demands and shifting priorities.
• Self-motivated with good interpersonal skills and ability to work effectively in a fast-paced, collaborative environment.
• Adept in documenting and presenting findings clearly through laboratory notebook, reports, and presentations.
• Expertise in synthetic organic chemistry, with experience synthesizing peptides a plus.

Physical Demands:

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 40 pounds. Specific vision abilities required by this job include close vision and distance vision.

This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.

The noise level in the work environment is usually moderate.