Senior Associate Scientist, Translational Research, Oncology Full-time

Senior Associate Scientist, Translational Research, Oncology

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

The Protein Homeostasis Research Center (TRC) at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The Protein Homeostasis TRC has a major focus of exploiting BMS' expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable. The group integrates discovery research through translational and early clinical development and exploits state-of-the-art in vitro, in vivo, and ex-vivo models of cancer biology to identify and validate targets and partners closely with colleagues in Translational Development, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.

Position Summary This role is for a bench-facing research position primarily focused on in-vitro techniques supporting translational biomarker work, indications, and assay development. A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability will be helpful.

The qualified candidate will demonstrate the following:

• Highly motivated, collaborative, and creative
• Ability to work across a highly matrixed environment to develop and implement experiments supporting translational development of novel therapeutics in oncology
• Self-starter and team player who can effectively collaborate with colleagues in the protein homeostasis, oncology, protein engineering/antibody development, chemistry, biomarker, and clinical groups.
• Proven track record in a relevant scientific area and strong technical skills
• Clear and professional verbal and written communication skills, capable of presenting scientific results to multidisciplinary teams and key stakeholders
• Experience evaluating and applying technologies in genome, transcriptome, and proteome characterization to preclinical and clinical samples

Key Responsibilities

In the role as a Senior Associate Scientist within Translational Research, the ideal candidate will:

• Conduct full time laboratory-based research supporting translational research experiments in the context of preclinical and early-phase clinical trials
• Participate on cross-site, cross-functional, and geographically diverse teams.
• Work with translational scientists whose activities span cell-based, in vivo, and clinical trial assays, samples, and data.
• Work on selection, validation, and deployment of novel clinical-stage assays and analyses of data to accelerate development and provide insight into disease biology and drug mechanisms.
• Execute experiments to test hypotheses from clinical observations in preclinical model systems.
• Review scientific papers/protocols and apply appropriately to project needs.
• Help execute collaborative projects with leading academic and commercial research groups worldwide.

Experience =

• Bachelor's Degree
• 4+ years of academic and / or industry experience

• Or
• Master's Degree
• 2+ years of academic and / or industry experience

Preferred Qualifications

• B.S. in a scientific discipline with at least 5 years of work experience or M.S. with at least 3 years of experience, preferably in industry and cancer biology.
• Hands on experience with various in-vitro cellular and biochemical assays, including:
• 2D/3D cell culture (BSL2+)
• in-vitro assays (e.g., co-cultures, transfections, shRNA, CRISPR technology, CTG, IncuCyte, and other cell-based assays)
• in-vivo sample processing (xenografts and other specimens)
• RNA analyses (e.g., qPCR, Nanostring)
• protein analyses (e.g., Westerns, MSD, ELISAs, Flow Cytometry, IP, HCS, IHC, fluorescent microscopy)
• Familiarity with next-generation sequencing technologies, including RNA-seq, whole exome/genome sequencing, ChIP-seq
• Aptitude in experimental design, execution, data analysis and troubleshooting. In touch with new technology, assays, automation, and innovative in approaches to complex problems.
• Data mining proficiency with public and internal databases (e.g., UCSC genome browser, DepMap, cBIO).
• Proficiency in utilizing software such as Graph Pad, E-notebook, Microsoft office, FlowJo, etc. for data analyses and figure generation.
• Attention to detail with excellent organizational and record keeping skills.
• Excellent interpersonal skills with the ability to interact effectively with diverse types of people, internally and externally.
• Familiarity with the drug development process, translational work, and knowledge of assay design, creation, and validation.
• Ability to stay focused, with attention to details, and to deliver high quality data in a timely and well-organized manner.
• Ability to handle multiple projects and work in a fast-paced dynamic team environment.
• Initiative, responsibility, and flexibility to adapt to changes with a positive attitude.