Senior Principal Scientist – Bioanalytical Research Full-time

Expert Scientist In Small And Large Molecule Mass Spectrometry

The Bioanalytical Research Group (BAR) in Investigative ADME/Toxicology and BioAnalytical Research at Louisville, CO is seeking an expert scientist skilled in small and large molecule mass spectrometry to deliver innovative ways to support Lilly's oncology portfolios. This role has an emphasis on bioanalysis of small molecule drug, especially radioligand therapeutics (RLT), with the possibility to expand into antibody-drug conjugates (ADC).

Primary responsibilities include:

• Perform sample preparation and operate mass spectrometer to develop bioanalytical methods and perform quantitative bioanalysis of small molecule or/and large molecule therapeutics from in-vitro and in-vivo samples.
• Investigate the structure-activity relationship including pharmacokinetics, biodistribution, biotransformation and metabolite identification of drug molecules using LC-MS/MS.
• Collaborate with ADME project leaders to support fast-paced drug discovery projects. Serve as bioA representative and provide bioanalytical expertise to project team.
• Mentor junior scientists in developing their skills in LC-MS sample preparation, data analysis, visualization and reporting.
• Maintain and troubleshoot lab instruments to ensure their operation.

Job requirements include:

• Bachelor's degree in science or engineering with at least 7 years of work experience, or master's degree in related field with at least 5 years of work experience.
• Experience with using inductively coupled plasma, triple quadrupole, high-resolution mass spectrometer in bioA method development, qualification, and transfer.
• Experience with small and large molecule bioanalysis, including sample preparation, sample extraction prior to MS.
• Experience of drug ADME principles in understanding PK, biodistribution and biotransformation of small and large molecule therapeutics.
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role.

Preferred qualifications include:

• Experience with discovery and development of radioligand therapeutics and elemental analysis using Agilent 8900 ICP-MS. Hands-on experience in sample preparation, LC-MS bioanalytical workflow to support the bioA and metID of RLTs.
• Familiar with bioanalytical workflow of biotherapeutics, including immunoprecipitation, proteolytic digestion and deglycosylation. Bottom-up peptide, payload quantification using Sciex 6500/7500. Intact mass acquisition, top-down MS using Thermofisher Orbitrap Exploris 240/480/Tribrid instruments.
• Familiar with MS-related informatic tools to conduct in-depth data analysis – Mass Hunter, Biopharma Finder, QuantBrowser, MultiQuant, Biologics Explorer, Protein Metrics, MassMetaSite, etc. AI-based data analysis and report writing are an advantage.
• Previous experience in experiment documentation, PK calculation, data visualization and report QC.
• Hands-on experience in automation instruments to support high-throughput bioanalytical assays.

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Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 – $213,400.

Full-time equivalent employees also will be eligible for a company bonus and a comprehensive benefit program.