Senior Principal Scientist, Bioprocess Development Full-time

Senior Principal Scientist

We are seeking a highly motivated Senior Principal Scientist to lead the Polysaccharide Fermentation and Purification Development group within Vaccines, Early BioProcess Development. The successful candidate will lead the group, provide strategic, innovative scientific and technical leadership for upstream and downstream bioprocess development supporting diverse vaccines portfolio.

This role is part of a cross-functional team focused on polysaccharide fermentation and purification process development for carbohydrate- and other modality-based conjugate vaccines. The successful candidate will be responsible for the development of scalable manufacturing processes across microbial fermentation, purification and scale up, shaping process development plans, integrating technical input across disciplines, mentoring scientific staff, managing risks, and influencing key program decisions from early-stage development through technology transfer and clinical manufacturing readiness.

Role Responsibilities:

• Lead and develop a high-performing team of upstream and downstream process development scientists and engineers, drive the vaccines program, while setting scientific direction, establishing priorities, building technical capability, and ensuring high standards for rigor, quality, and accountability.
• Drive development of robust, scalable, and transferable manufacturing processes.

Basic Qualifications:

• PhD in Chemical Engineering, Biochemical Engineering, Bioengineering, Microbiology, Biochemistry, or a related discipline, with a minimum of 8 years of relevant experience.
• Demonstrated expertise in vaccine process development, preferably for capsular or exopolysaccharides, conjugate vaccines, bacterial antigens, carrier proteins, or other microbial-based vaccine platforms.
• Hands-on technical depth in microbial fermentation and developing polysaccharide recovery and purification processes.
• Strong knowledge of polysaccharide critical quality attributes, in-process controls, design of experiments, scale-down model development, and process characterization.
• Ability to drive projects, translate scientific strategies into executable development plans, manage competing priorities, and guide teams through ambiguity while maintaining accountability for program deliverables.
• Excellent organizational, interpersonal, and communication skills to effectively influence and collaborate in a fast-paced, multi-disciplinary team environment.

Physical/Mental Requirements:

• Standard laboratory conditions – sitting, standing, primarily lab based
• Ability to perform mathematical calculations and ability to perform complex data analysis

Additional Details:

• Work Location Assignment: On Premise
• Last date to apply is September 28, 2026