Senior Principal Scientist, Cancer Immunology, Discovery Biology, Oncology Thematic Research Center Full-time

Senior Principal Scientist, Cancer Immunology, Discovery Biology, Oncology Thematic Research Center

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

The Oncology Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. Housed in state-of-the-art research and development sites in Cambridge and Seattle and embedded in vibrant ecosystems of research and innovation. The Oncology teams drive novel therapeutic interventions exploiting tumor intrinsic pathways and mechanisms of cancer immunology to treat tumors that are refractory to current treatments. We are fully integrated from drug discovery through translational and early clinical development using state-of-the-art in vitro, in vivo and ex-vivo models of cancer and immune biology to identify and validate novel targets and therapeutic approaches. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Position Summary:

We are seeking an innovative immunologist and leader to help shape our strategy and advance our portfolio of pioneering T cell engager and cancer immunology therapies to treat cancers. As a successful candidate you will be part of a multi-disciplinary, groundbreaking team within Discovery Biology at the Oncology Thematic Research Center in Seattle, WA, driving projects from concept to clinic, leveraging proprietary technologies and collaborating with top experts in the field. You will work with leadership to define strategy, provide mentorship to junior scientists, and drive multi-functional teams to bring both internal and external assets to patients. Our team thrives on creativity, rigorous science, and a shared commitment to transforming cancer care.

Position Responsibilities:

In the role as a Senior Principal Scientist within Discovery Biology, the ideal candidate will:

• Lead matrixed TCE / cancer immunology discovery teams from target concept to IND and lead/mentor a biology team supporting in vitro experimentation.
• Deploy existing and new techniques for function-based identification and selection of lead drug candidates
• Leverage experience and insights to shape overall strategy and inform the next wave of therapeutic innovation.
• Collaborate with functional area leads e.g. pharmacology, DMPK, bioinformatics to drive programs forward, including helping to define program priorities and risks.
• Collaborate with multi-disciplinary teams from external partners to help drive assets forward.
• Present complex concepts to a range of audiences including governance and full team project meetings.
• Utilize excellent communication and interpersonal skills.
• Communicate via email, meetings, and reports.

Experience:

Basic Qualifications:

• Bachelor's Degree
• 10+ years of academic and / or industry experience
• Or
• Master's Degree
• 8+ years of academic and / or industry experience
• Or
• Ph.D. or equivalent advanced degree in the Life Sciences
• 6+ years of academic and / or industry experience
• 2+ years of leadership experience

Preferred Qualifications

• Ph.D. or equivalent advanced degree in the Life Sciences
• 6+ years of industry experience
• 2+ years of leadership experience
• Experience developing novel immune therapeutic approaches for cancer including T cell redirected therapies.
• Experience leading teams charged with profiling and developing complex biologics to drive enhanced immune function in the tumor microenvironment, with a strong preference for experience in discovery of T cell engagers.
• Experience in both high throughput screening, and biologically complex, cell based assays to drive mechanistic insight and prioritization of therapeutic leads. Experience in interpreting in vivo functional assays.
• Experience leading and collaborating across matrixed discovery programs from concept to IND including with immune cell engagers.
• Experience contributing to an IND.
• Strong leadership, interpersonal, and communication skills.
• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.
• Ability to summarize and interpret complex scientific data in a clear, concise, and accurate manner.
• Experience leading, coaching and mentoring a team of lab-based in vitro biologists.
• Excellent oral and written communication skills.
• Ability to communicate well with peers, supervisors, and governance committees.
• Strong problem-solving skills and understanding of complex scientific principles and demonstrated experience leveraging AI to refine strategic and tactical planning.

Compensation Overview:

Seattle – WA: $174,020 – $210,872

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients' lives through science™ “, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a