Senior Principal Scientist, Lab Head, Immunomodulation / Cell Reprogramming Full-time NEW

Pursue Progress, Discover Extraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn't happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let's be those people.

Sanofi provides equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Senior Principal Scientist, Lab Head, Immunomodulation – Cell Reprogramming

Location: Cambridge, MA

Sanofi Oncology is seeking a highly motivated individual with project leadership experience and deep knowledge in immuno-oncology. This individual will play a leading role in developing novel cell reprogramming and other therapies aimed at modifying the tumor microenvironment to treat cancer. The successful candidate will lead a team within the Immunomodulation & Cell Reprogramming Cluster where they are expected to support progression of existing programs, develop new projects, and contribute to the growth of the Immuno-Oncology portfolio. The position is based in Cambridge, Massachusetts, USA.

Join the engine of Sanofi's mission — where deep immunoscience meets bold, AI-powered research. In R&D, you'll drive breakthroughs that could turn the impossible into possible for millions.

We're an R&D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people's lives.

Main Responsibilities

• Lead and manage a team of scientists and cross-functional research teams, ensuring timely progression of projects from early concepts to first-in-human studies
• Mentor and develop team members, fostering scientific excellence, professional growth, and a lead-by-example culture
• Develop clear scientific strategies to support departmental goals and allocate resources to drive overall group performance
• Demonstrate innovation in research with deep understanding of clinical translation
• Apply scientific expertise to initiate, design, direct, and execute experiments while ensuring compliance with laboratory safety and documentation protocols
• Keep current with developments in basic research, clinical development, and the competitive landscape
• Publish and present findings in peer-reviewed journals and scientific conferences

About You

Basic Qualifications:

• Ph.D. in Immunology, Immuno-Oncology, Cell Biology, Molecular Biology, or related discipline
• Minimum of 7 years of post-graduate research experience in the pharmaceutical, biotechnology, or related industry
• Deep knowledge in immunological mechanisms or tumor immunology
• Experience in cell therapy and/or tumor microenvironment research
• Hands-on experience in isolation and immune phenotyping of murine and human immune populations (e.g., cell sorting, flow cytometry), functional assessment of immune subsets (e.g., proliferation, cytotoxicity, cytokine/chemokine measurement), and murine tumor models including immune deficient and humanized mice
• Familiarity with techniques for genetically modifying immune cells to express novel transgenes
• Excellent organizational, communication, and presentation skills with the ability to work both collaboratively and independently

Why Choose Us:

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.
• Help improve the lives of millions of people globally by making drug development quicker and more effective.
• Achieve genuine work-life balance in a supportive R&D environment.