Senior Research Fellow Full-time

Senior Research Fellow

An experienced Senior Research Fellow is required for projects developing the next generation of therapies for children with blood and immune disorders, including CAR T cells for leukaemia. The postholder will design, generate and investigate strategies to improve CAR T cell and haematopoietic stem cell therapies in pre-clinical studies. They will also require experience in human cell engineering using techniques such as RNA-guided editing and lentiviral transduction. There will be close working with university and hospital partners, and supervision of junior staff and students. Team working, aptitude and excellent communication and record keeping skills will be essential. The postholder will have skills for investigating genome editing of T cells/haematopoietic stem cells, high throughput and single cell analysis and humanised models. This is an exciting opportunity in a rapidly emerging area of translational medicine. The post is funded by GOSHCC and will be appointed for 12 months in the first instance with scope for extension.

The successful candidate is expected to have the following; Expertise in human T cell and/or stem cell handling, culture, genome editing, flow cytometry, and functional assays. Skills for humanised models of adoptive therapy and stem cell engraftment. Experience in the design and testing of genome editing tools (CRISPR/Cas, base and prime editing) and associated sequencing and bioinformatics. Experience with NGS, WGS and single-cell RNA analysis (scRNA). Ability to handle and interpret sequencing and single-cell datasets. Established record of PhD supervision to completion.

As well as the exciting opportunities this role presents we also offer some great benefits some of which are below: 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days) Defined benefit career average revalued earnings pension scheme (CARE) Cycle to work scheme and season ticket loan On-Site nursery On-site gym Enhanced maternity, paternity and adoption pay Employee assistance programme: Staff Support Service Discounted medical insurance

As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here.