Senior Scientist, AI Applications – R&D Oncology Full-time

Senior Scientist, AI Applications, R&D Oncology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

Johnson & Johnson Innovative Medicine is recruiting for a Senior Scientist, AI Applications, R&D Oncology to join our Data Science and Digital Health team (DSDH). This position will be located at one of our offices in either Spring House PA (preferred), Cambridge MA, or San Diego CA (La Jolla area). Consideration may be given for our Titusville and Raritan, NJ locations. The Senior Scientist, AI Applications will work closely with the Machine Intelligence (MI) team within Data Science and Digital Health (DSDH) AI/ML to develop and deliver artificial intelligence (AI)/machine learning (ML) scientific applications. This is a role for a mission-driven Scientist aimed at developing the future of autonomous AI in oncology drug discovery and development.

Key Responsibilities:

• Work with Oncology R&D and Data Science business leaders to translate business opportunities into hands on research plans.
• Develop and optimize multimodal reasoning systems that integrate large-scale structured and unstructured data to derive actionable conclusions.
• Build novel agent memory architectures to enable persistent knowledge retention and context-aware decision-making across extended discovery workflows.
• Prototype and evaluate innovative approaches for uncertainty quantification and reliability assessment in AI-driven scientific reasoning.
• Serve as a domain expert within the field by articulating to team members emerging approaches and methodologies within the AI/ML with a clear understanding of their practical applications within the industry.
• Benchmark agent performance against human expert decisions and existing computational methods and demonstrate ability to publish results in leading journals and conferences.
• Define and enforce engineering best practices across AI prototyping, including architecture patterns, documentation standards, quality gates, and reproducibility criteria.
• Serve as a key contributor to the over-arching AI strategy and to enable the scaling and deployment of tools aimed at the broader R&D community.

Required Qualifications:

• A Ph.D. degree in AI/ML or related field (e.g., computer science, machine learning, data science, applied mathematics, statistics) with at least two (2) years working experience.
• Knowledge in sophisticated mathematics areas such as Bayesian inference, uncertainty quantification, information theory, causal inferencing, graph neural networks, etc.
• Proficiency with open-source agentic frameworks (e.g., LangGraph, DSPy, mem0, etc.) and deep learning frameworks (e.g., PyTorch, Tensorflow, etc.)
• Proficiency in one or more programming languages – preferably Python

Preferred Qualifications:

• Understanding of drug discovery pipeline and familiarity with biological data types, experience in oncology research
• Strong understanding of statistics and applicable methods to validate model performance
• Familiarity with cloud hosting solutions (ex. AWS and/or Azure)

This position will be located at one of our offices in either Spring House PA (preferred), Cambridge MA, or San Diego CA (La Jolla area). Consideration may be given for our Titusville and Raritan, NJ locations. (No remote option.) Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.