Senior Scientist – Bioanalytical & Biomarker Technologies Full-time

Bioanalytical Scientist

We are seeking a highly motivated bioanalytical scientist who can contribute to the development and implementation of state-of-the-art quantitative and qualitative analytical and bioanalytical methods to support biopharmaceuticals in discovery and preclinical development pipeline at Regeneron. The successful candidate need function well in a collaborative, fast-paced, multidisciplinary team environment.

A typical day in this role looks like:

• Primarily responsible for developing LC-MS-based bioanalytical methods in various biological matrices.
• Apply these methods to quantify biotherapeutic levels, assess in vitro stability, evaluate in vivo biotransformation, and measure biomarkers (small molecules, peptides, and proteins).
• Support characterization of drug candidates and critical reagents within the discovery pipeline.
• Collaborate closely with chemistry, conjugation, biology, PK, and TK teams to ensure strong experimental design, accurate data interpretation, and informed decision-making.
• Contribute to advancing programs involving bioconjugates, oligonucleotides, bispecifics, and other therapeutic modalities.
• Explore and evaluate innovative bioanalytical technologies and emerging platforms to support an evolving portfolio, including novel molecular modalities and therapeutic areas.
• Document experiments, results, and findings in an electronic lab notebook.
• Present scientific work at internal and external meetings.
• Perform general lab and instrument maintenance.
• Grow into the role of bioanalytical representative on cross-functional project teams, effectively managing priorities to meet multiple project goals and timelines.

This role may be for you if you have experience:

• Chemistry, Biochemistry, Pharmaceutical Science or a related discipline, B.S. with 10+ yrs, MS with 8+ yrs, or Ph.D. with 0-6 yrs postdoctoral experience.
• Proven expertise and extensive experience in liquid chromatography and mass spectrometry is required, with demonstrated track record of successfully developing MS, LC-MS or LC-MS/MS method.
• Hands on experience in sample preparation technique (LLE, SPE, Immunocapture, enzymatic digestion, homogenization etc.) and automation platform.
• Scientific curiosity and strong capabilities in experimental design, execution, data interpretation and troubleshooting with limited supervision.
• Ability to think critically and to prioritize and manage multiple projects under aggressive timeline in a fast-paced environment.
• Detail-oriented, good interpersonal and effective technical writing and verbal communication skills.
• Industrial experience in bioanalysis of LC-MS based small molecule, siRNA, biomarkers and biotherapeutics assay development is preferred. Job level may be adjusted based on the experience.
• Previous experience in GLP lab and mass spectrometry applications in ADC analytics, metabolomics and proteomics would be advantageous.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually): $109,900.00 – $179,300.00