Senior Scientist – Bioinformatics Full-time

Computational Scientist

The Molecular Profiling and Data Science Department is looking for an enthusiastic and motivated Computational Scientist who values independent research in an open and collaborative working environment. You will participate in original studies that span from basic research to translational studies, directly impacting the lives of patients.

You will join a diverse and inspiring team which leverages bioinformatic strategies to optimize key aspects of gene therapeutic products, including expression, stability, splicing, and translation. You will work closely with the Regeneron Genetic Medicines Technology Center (RGM) to advance therapeutic development through cutting-edge computational support. You will utilize genomic and transcriptomic profiling sequencing tools to engineer delivery vehicles, evaluate therapeutic cargo efficacy, and identify the off-target effects of the delivered payload.

In this role, a typical day might include the following:

• Lead computational on-target and off-target characterization of gene therapy programs, utilizing both empirical NGS datasets and in silico prediction models.
• Build and refine models to predict, score, and prioritize therapeutic off-target effects across the transcriptome and genome.
• Use computational approaches to optimize expression of therapy payloads (siRNA, shRNA, snRNA and microRNA) and delivery of viral and non-viral vehicle technologies.
• Develop internal tools, pipelines, workflows, and documentation that raise the analytical standards of the Molecular Profiling and Data Science group.
• Contribute with technical expertise on discussions of research efforts conducted by your and other departments in the company.
• Prepare and deliver clear, concise scientific presentations for collaborators and senior management.

This job might be for you if you:

• Have a strong background in gene therapy and differential gene expression analysis.
• Have direct experience or is very familiar with the production of a range of NGS datasets.
• Bring innovative thinking to multi-omics data analysis.
• Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward within Regeneron.
• Can effectively communicate with collaborators of various scientific backgrounds.
• Value teamwork and team excellence.

In order to be considered for this role, you must have:

• Ph.D. in Data Science, computational biology, or related field
• 0-2 years of relevant experience