Senior Scientist, CAR Screening and Lead Selection (CGM) Full-time

Senior Scientist, CAR Screening and Lead Selection (CGM)

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

We are searching for the best talent for a Senior Scientist, CAR Screening and Lead Selection (CGM), to be based in Cambridge, MA. Purpose: We are seeking an experienced and highly motivated Senior Scientist to join our CAR Screening and Lead Selection, Cell & Genetic Medicines team focused on advancing next-generation cell therapies. The Senior Scientist will design, execute, and analyze in vitro assays to characterize and select CAR-T candidates, supporting data-driven decisions that drive pipeline progression. This role offers the opportunity to work cross-functionally in a dynamic, fast-paced environment with cutting-edge technologies.

You will be responsible for:

• Contribute to advancing pipeline programs by generating assays and data sets that stratify lead CAR-T candidates.
• Design, perform, and troubleshoot in vitro assays to evaluate the phenotype and function of CAR-T cell candidates, including cell-based cytotoxicity assays.
• Thorough analysis of complex data sets, applying results towards determining next-step strategies and troubleshooting.
• Collaborate closely with colleagues in discovery, process development, and therapeutic area teams to align priorities and share data.
• Contribute to broader team experimental designs, scientific strategy discussions and provide guidance and support to junior team members.
• Follow best practice lab operations for safety, data integrity, and reproducibility.
• Maintain meticulous records of experimental design, data, and analysis using electronic lab notebook (ELN).

Qualifications:

• PhD in immunology, cell biology, or a related field with 2+ years of relevant industry or postdoctoral experience; Bachelor's or Master's degree with 4-6 years of experience will also be considered.
• Extensive hands-on experience with multiparameter flow cytometry, including panel design, sample preparation, acquisition, and data analysis.
• Experience with spectral flow cytometry is preferred.
• Experience with intracellular cytokine staining and cytokine arrays, such as MSD or comparable.
• Proficiency in IncuCyte-based assays or comparable real-time cytotoxicity platforms.
• Demonstrated expertise using ELN systems for experimental documentation, experience with Benchling a plus.
• Advanced skills in data analysis and presentation using GraphPad Prism, Spotfire or similar software.
• Strong problem-solving skills and the ability to independently drive projects while working collaboratively.
• Excellent written and verbal communication skills.

This is an on-site lab-based role; candidates must be comfortable with extensive bench work and collaborative team science. This role may require up to 10% travel.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

Required Skills: Accelerating, Analytical Reasoning, Clinical Data Management, Critical Thinking, Data Analysis, Data Reporting, Data Savvy, Design of Experiments (DOE), Drug Discovery Development, Issue Escalation, Molecular Diagnostics, Pharmaceutical Microbiology, Product Knowledge, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Technologically Savvy

Preferred Skills: Accelerating, Analytical Reasoning, Clinical Data Management, Critical Thinking, Data Analysis, Data Reporting, Data Savvy, Design of Experiments (DOE), Drug Discovery Development, Issue Escalation, Molecular Diagnostics, Pharmaceutical Microbiology, Product Knowledge, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Technologically Savvy

The anticipated base pay range for this position is: $109,000.00 – $174,800.00