Senior Scientist, Epithelial and Stromal Biology – San Carlos, California Full-time

Senior Scientist

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

Candidates must be able to work onsite in San Carlos, California. At BeOne Institute, we extend BeOne's execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:

• Bold exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.
• Strategic alignment: we prioritize disease areas that align closely with BeOne's R&D priorities and long-term vision.
• Pipeline impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

As a Senior Scientist at BeOne Institute, you will independently design and execute high-quality research studies supporting discovery and translational programs in immunology, inflammation, and immuno-oncology. You will contribute to target evaluation, mechanistic understanding, and therapeutic development through generation of rigorous, decision-enabling data.

Essential functions of the job:

• Identify and advance high-value therapeutic targets across immunology, inflammation, and immuno-oncology therapeutic areas, aligned with organizational strategy, portfolio priorities, and emerging scientific opportunities.
• Independently design, execute, analyze, and interpret in vitro, ex vivo, and in vivo studies to validate target biology, establish disease rationale, evaluate therapeutic modalities, develop mechanistic insight, and generate decision-enabling data packages.
• Communicate progress through regular updates while proactively identifying challenges and proposing solutions.
• Collaborate with cross-disciplinary or cross-functional teams and drive innovation within and beyond the Institute.
• Contribute to management and operational activities to support strategic objectives of the BeOne Institute at the San Carlos site.

Supervisory responsibilities:

• May mentor junior scientists, research associates, interns

Requirements:

• Ph.D., M.D., or equivalent advanced degree in one or more of the following areas: cancer biology, immuno-oncology, immunology, epithelial and stromal biology, stem cell biology, or a related life sciences discipline. 2+ years of related experience.
• Demonstrated track record of scientific achievements, as evidenced by publications in high-impact journals.
• Demonstrated ability to design experiments, generate high-quality data, analyze complex datasets, and communicate scientific findings effectively.
• Hands-on experience with relevant laboratory techniques such as primary human/mouse epithelial and stromal cell culture, air-lift culture, epithelial organoid culture, cell line engineering, histology, IHC, IF, flow cytometry, ELISA, MSD, molecular biology methods, protein characterization, microscopy/high-content imaging, or related experimental platforms.
• Experience with one or more of the following is preferred: in vitro and in vivo disease models, AI-driven protein design, protein engineering, induced proximity technologies, synthetic biology approaches, or other innovative therapeutic platforms.
• Knowledge of biologics, small molecules, and other complex modalities, experience with omics data analysis, and/or preclinical immunology and oncology mouse models is a plus.
• Ability to operate effectively in a highly collaborative, fast-paced, and interdisciplinary research environment, and to integrate multi-disciplinary approaches to solve complex biological problems.
• Strong collaboration skills across functional and disciplinary boundaries.
• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences.

Education required:

Ph.D., M.D., or equivalent advanced degree

Travel: No

Global competencies:

• Fosters teamwork
• Provides and solicits honest and actionable feedback
• Self-awareness
• Acts inclusively
• Demonstrates initiative
• Entrepreneurial mindset
• Continuous learning
• Embraces change
• Results-oriented
• Analytical thinking/data analysis
• Financial excellence
• Communicates with clarity

Salary range: $150,200.00 – $187,800.00 annually

BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non-commercial roles are eligible to participate in the annual bonus plan, and commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes medical, dental, vision, 401(k), FSA/HSA, life insurance, paid time off, and wellness.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status, or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state, or local laws, applicants who require reasonable accommodation in the job application process may contact accommodationsus@beonemed.com.