Senior Scientist, Gene Delivery and Editing Process Development Full-time

Senior Scientist, Gene Delivery and Editing Process Development

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

The Senior Scientist will join the Gene Delivery and Editing Process Development (GDEPD) organization supporting process development, production, and characterization of viral vectors, which are critical to generating BMS's groundbreaking cell therapies. The candidate will help drive next-generation viral vector platform development and support the advancement of clinical programs.

Responsibilities:

• Design, execute, and troubleshoot upstream development experiments supporting next-generation LVV and AAV production
• Identify, onboard, and develop novel upstream technologies in collaboration with internal and external partners
• Optimize production processes and support clinical and commercial scale-up
• Ability to design, execute, and lead a platform development strategy, including coordinating the work of junior colleagues and peers
• Craft and articulate timelines and resource projections
• Leverage knowledge of business needs to communicate progress, risks, and opportunities to senior leaders in the organization
• Support cross-functional development efforts e.g. downstream process development, analytical development, pilot plant production, high-throughput process development, etc.
• Support research-to-development transitions, including early-stage/pipeline molecular assessment activities
• Support late-stage process development activities including process characterization
• Actively participate and support lab maintenance, buildout, and continuous improvement initiatives
• Work independently and within teams to design, execute, and analyze experiments
• Flex between platform development and program development work as necessary
• Summarize and present data in group meetings and contribute to group discussions and team strategy
• Represent GDPAD within cross-functional teams
• Support tech transfer and on-going activities with external collaborators and service providers (CDMOs, CROs)
• Model sophisticated knowledge management through authoring of detailed technical reports, study memos, and internal and external presentations/publications
• Maintain accurate and detailed laboratory notebook

Basic Qualifications:

• Degree in biological or chemical engineering, biochemistry, or bio-related field. PhD with 1+ year relevant industry experience; MS with 5+ years of relevant industry experience; BS with 7+ years relevant industry experience. Title/compensation will ultimately be commensurate with education, experience, and skillset
• Subject matter expert with suspension culture of mammalian cells in shake flasks and stirred tank bioreactors
• Subject matter expert in process development
• Expertise in viral vector process development
• Working knowledge of scale up parameters for stirred tank bioreactors
• Proven ability to design experiments with DoE approaches, execute DoE designs and interpret the results
• Independently motivated with ability to work in cross-functional teams
• Experience interfacing with contract manufacturing and development organizations
• Ability to communicate clearly and concisely through oral presentations and technical writing
• Ability to leverage literature, internal and external resources to solve problems
• Desire to identify and advance the cutting edge
• Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment
• Experience giving presentations at industry conferences
• Experience establishing industry (e.g. vendor) and/or academic collaborations

Preferred Qualifications:

• Experience with upstream processes intensification e.g. fed batch and perfusion development, process-analytical technology (PAT)
• Experience with cell line development
• Experience with media and feed development and optimization
• Experience with process modeling, mechanistic modeling, and statistical interpretation of results
• Knowledge of metabolic flux and metabolic control analysis
• Experience with data pipelines and knowledge management
• Experience with late-stage development
• Track record of intellectual property generation

Additional Job Requirements:

• Position Handles Hazardous Materials
• Position may require occasional travel (e.g. up to 10%)

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn't perfectly match your resume, we encourage you to apply anyway.

Compensation Overview:

Seattle – WA: $124,190 – $150,483

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits