Senior Scientist I Full-time

Job Title

We are looking for a motivated candidate to support late-stage process development of Antibody-Drug-Conjugates (ADCs) and other emerging conjugation modalities.

Responsibilities

• Maintain a high degree of productivity in lab to support conjugation process development: independently design, execute, and interpret key experiments to answer scientific questions.
• Perform conjugation and purification operations at reaction scales ranging from ~mL scale reactions up to a 10L reactor.
• Perform routine sample preparation and operation of HPLC-based analytical assays.
• Understand scale dependence of chemical reactions or purifications, or engineering scale factors.
• Document and share results via electronic laboratory notebooks, internal technical presentations, and technical reports.
• Learn, understand, and master relevant laboratory techniques, and serve as a subject matter expert and mentor for junior scientists in lab.
• The candidate will understand and adhere to corporate standards regarding code of conduct, safety and GXP compliance.
• Work collaboratively within a multi-disciplinary team, including analytical chemists, process chemists, and manufacturing personnel.

Qualifications

• BS with 10+ years', MS with 8+ years', and PhD with 0+ years' industry experience.
• Degree in chemistry or chemical engineering.
• Strong scientific communication and interpersonal skills to drive collaboration within the conjugation process development team and with cross-functional partners.
• Thorough understanding of organic chemistry, theoretical conceptualization of reaction mechanisms, and practical 'fluency' with wet-lab operations and running chemical reactions.
• Extremely knowledgeable in HPLC/UPLC instruments: familiar with equipment care and maintenance best practices for shared lab equipment, ability to perform basic troubleshooting of HPLC systems.
• Ability to multitask and meet timelines.

Preferred Qualifications

• Prior experience with drug-conjugate chemistry or conjugation process development is not necessary but strongly preferred.
• Advanced degree (MS or PhD) in organic chemistry, or experience in small molecule chemistry.
• Experience in design-of-experiments (DoE), quality-by-design (QbD), and development of statistical and mathematical models

Additional Information

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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Pay Range: $96500 – 183500 USD

Where We Work

Role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely*, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.