Senior Scientist I/II, Precision Medicine Translational Research Immunology Full-time

Job Title

The Precision Medicine Immunology department is seeking a highly motivated and talented Scientist with a background in immunology or immuno-oncology and experience in single-cell or spatial genomics, molecular biology, and cell biology to join the Translational Research team.

Key Responsibilities

• Independently lead the design, execution, and analysis of complex genomic profiling experiments, including single-cell RNA-Seq, CITE-Seq, and spatial transcriptomics/proteomics.
• Perform image analysis tasks for spatial transcriptomics and proteomics datasets, including de-array and alignment for multi-omics integration, cell segmentation and phenotyping.
• Design, develop and implement computational pipelines for processing and analyzing spatial omics datasets, including spatial transcriptomics and proteomics.
• Proactively identify technical artifacts, interpret quality control results, optimize assay performance, and ensure high quality and reproducible data delivery on timely deadlines.
• Stay at the forefront of the single-cell and spatial genomics field by surveying, evaluating, testing and validating novel scientific methodologies.
• Present work plans and acquired data clearly and precisely to cross-functional stakeholders through formal written reports and verbal updates

Qualifications

• Bachelor's Degree or equivalent education and typically 12 years of experience, Master's Degree or equivalent education and typically 10 years of experience, PhD and typically 4 years of experience.
• Major or advanced degree in Immunology, cell & molecular biology, pharmacology, pathology, bioinformatics or other relevant biological sciences.
• Proven track record of leading translational medicine initiatives in autoimmune diseases, bridging the gap between early discovery and clinical application.
• Extensive experience designing and conducting single-cell and spatial omics studies to generate and validate critical biomarker hypotheses.
• Broad technical expertise in molecular and cell biology assays, specifically specializing in scRNA-seq, CITE-seq, and multi-parameter flow cytometry.
• Expertise in executing spatial omics experiments using CosMx, Xenium, and Visium platforms, integrated with deep expertise in molecular pathology techniques such as IHC and ISH
• Proficient in the integrative analysis of multi-dimensional datasets using bioinformatics tools such as R and Python.
• Skilled in using advanced image analysis platforms, such as Visiopharm and HALO, to derive quantitative biological insights from tissue-based assays.
• Familiarity with cloud-based architectures (AWS) and high-performance computing (HPC) environments for processing large-scale genomic data.
• Experience applying machine learning frameworks and sophisticated data visualization tools to interpret complex biological patterns.
• Strong project leadership and organizational skills, with a demonstrated ability to prioritize tasks and allocate resources to meet aggressive timelines.
• Experienced in managing CROs and external collaborators while working seamlessly with multi-functional internal teams in dynamic, fast-paced environments.
• Excellent presentation and people management skills, with a proven ability to communicate complex scientific data to diverse stakeholders and executive leadership.
• A robust track record of scientific writing, ensuring high-quality documentation and verbal reporting of technical findings.

Additional Information

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our long-term incentive programs.

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1. Yes, 5% of the Time

Pay Range: $109500 – 208500 USD

Where We Work

Role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely*, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.