Senior Scientist I, siRNA Pipeline Development & Targeted Delivery Full-time

Senior Scientist I

At AbbVie, we are dedicated to solving some of the world's most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking for talented, passionate, and driven individuals to join our Biotherapeutics and Genetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.

AbbVie is looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

Responsibilities include:

• Leading research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development.
• Designing and executing in vitro and in vivo proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline programs.
• Designing and executing receptor expression profiling, ligand–receptor binding, internalization, and trafficking assays.
• Evaluating functional delivery and target knockdown in receptor-positive cells and tissues.
• Providing scientific leadership and expertise in candidate nomination and pipeline development.
• Working independently and maintaining a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
• Analyzing and interpreting multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Collaborating and effectively communicating results with key stakeholders and cross-functional teams throughout the organization.
• Contributing as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Mentoring and supporting junior scientists within the team.

Qualifications include:

• BS, MS, or PhD in chemistry, biology, biochemistry, pharmacology or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) of experience.
• Demonstrated expertise in siRNA candidate nomination and pipeline development.
• Demonstrated experience in drug delivery platforms, receptor biology and targeted delivery.
• Hands on experience of uptake, trafficking, and functional delivery assays.
• Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS) library preparation, protein assays (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification.
• Experience in assay development and high-throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.

Why AbbVie?

AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.

How to Apply

If you are passionate about advancing RNA-based therapeutics and have a track record of success in cell and molecular biology, we encourage you to apply! Please submit your resume outlining your relevant experience and why you would be a great fit for this position.

Additional Information

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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1. Yes, 5% of the Time

Pay Range: $96500 – 183500 USD

Where We Work

Role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely*, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.