Senior Scientist, In Vitro (Cardiometabolic Disease) Full-time

Senior Scientist Cardiometabolic Disease

The Cardiometabolic Disease (CMD) department at our company's Research Labs in South San Francisco is seeking a Senior Scientist to join our discovery team. This role offers an exciting opportunity to contribute to cardiovascular drug discovery by developing and applying robust cell-based and ex-vivo systems to advance understanding of disease biology and mechanism of action.

The successful candidate will demonstrate strong initiative, operating in a multidisciplinary, matrixed environment to identify, mechanistically validate, and advance novel therapeutic targets for cardiovascular disease. This role is well suited for an intellectually curious and driven scientist with a hypothesis-focused mindset who excels at integrating in vitro findings with preclinical in vivo and human-relevant insights to inform discovery-stage decisions.

Key Responsibilities:

• Independently design, optimize, and execute cell-based and ex-vivo assays to interrogate disease pathways and pharmacologic mechanisms.
• Lead mechanism-of-action studies using molecular, biochemical, and cellular approaches to link target modulation to disease biology.
• Generate high-quality, reproducible data and apply critical analysis to guide decision-making and prioritization.
• Collaborate effectively with cross-functional teams to advance cardiovascular drug discovery programs.
• Incorporate emerging assay technologies to strengthen discovery capabilities.
• Stay current with scientific advances in cardiovascular and translational biology.
• Communicate scientific rationale, assay strategies, and key findings clearly to diverse audiences.
• Maintain rigorous documentation in electronic lab notebooks and contribute to presentations, technical reports, and manuscripts.

Qualifications:

Education:

• Master's (with 4+ years) or Ph.D. (with 1+ years) in physiology, pharmacology, biomedical sciences or related field and relevant drug discovery experience.

Required Experience and Skills:

• Demonstrated expertise in designing, executing, and interpreting in vitro and ex-vivo experiments with high scientific rigor.
• Proven ability to independently drive experiments, troubleshoot assays, and derive actionable conclusions.
• Demonstrated creativity and problem-solving ability in addressing complex biological questions using state-of-the-art in vitro approaches (reflected by publications and/or impactful internal contributions).
• Proficiency in standard molecular, cellular, and biochemical techniques.
• Strong quantitative skills, including data analysis and application of statistical approaches to biological datasets.
• Excellent communication and organizational skills, with the ability to manage multiple projects in a matrixed environment.

Preferred Experience and Skills:

• Experience with primary or advanced cell culture systems (including 2D and 3D models) in cardiac or vascular biology.
• Strategic thinker with a background in one or more relevant areas (atherosclerosis, heart failure, inflammation, renal disease, lipid metabolism).
• Solid understanding of the translational strengths and limitations of in vitro models.
• Experience developing fit-for-purpose in vitro assays to support compound profiling and mechanism-based evaluation.
• Familiarity with multi-omics approaches (e.g., single-cell RNA-seq and proteomics) to support target biology and validation.
• Understanding of in vivo cardiovascular models and physiological endpoints.

Required Skills: Cardiometabolic, Cell Cultures, Ex Vivo Assays, In Vitro Assays, In Vitro Models, In Vitro Studies, Vascular Biology

Preferred Skills: