Senior Scientist, Systems Immunology – San Carlos, California Full-time

Senior Scientist

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

Candidates must be able to work onsite in San Carlos, California. At BeOne Institute, we extend BeOne's execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:

• Bold exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.
• Strategic alignment: we prioritize disease areas that align closely with BeOne's R&D priorities and long-term vision.
• Pipeline impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

As a Senior Scientist at BeOne Institute, you will lead and execute cutting-edge genomics and systems immunology studies supporting discovery and translational programs in immunology, inflammation, and immuno-oncology. You will leverage single-cell and bulk multi-omics technologies to uncover disease mechanisms, identify novel therapeutic targets, characterize immune responses, and generate actionable biological insights that enable therapeutic innovation. Working closely with discovery biologists, computational scientists, and translational teams, you will integrate complex molecular and cellular datasets to drive high-impact research programs.

Essential functions of the job:

• Design, execute, and interpret multi-omics studies supporting target discovery, target validation, and translational research in immunology, inflammation, and immuno-oncology.
• Independently develop experimental strategies utilizing single-cell RNA-seq, CITE-seq, ATAC-seq, spatial transcriptomics, immune TCR/BCR repertoire sequencing, immunopeptidomics, bulk RNA-seq, and related genomic technologies to characterize immune responses, clonal dynamics, antigen-specific populations to support therapeutic target discovery and mechanism of action studies.
• Collaborate closely with computational biology and research informatics teams to develop analytical pipelines, interpret complex datasets, and derive biologically meaningful conclusions.
• Design and implement in vitro experiments and translate omics findings into mechanistic hypotheses and actionable targets.
• Collaborate with cross-disciplinary or cross-functional teams and drive innovation within and beyond the Institute.
• Contribute to management and operational activities to support strategic objectives of the BeOne Institute at the San Carlos site.

Supervisory responsibilities:

• May mentor junior scientists, research associates, interns

Requirements:

• Ph.D., M.D., or equivalent advanced degree in one or more of the following areas: Immunology, Computational Biology, Genomics, Systems Biology, Cancer Biology, Bioinformatics, Molecular Biology, or a related life sciences discipline. 2+ years of related experience.
• Demonstrated track record of scientific achievements and innovation in genomics, immunology, or systems biology.
• Extensive hands-on experience designing and executing single-cell RNA sequencing (scRNA-seq), CITE-seq, ATAC-seq, immune TCR/BCR repertoire sequencing, immunopeptidomics or other next-generation sequencing-based technologies.
• Demonstrated expertise in TCR and BCR repertoire analysis, clonotype tracking, immune cell state characterization, and immune profiling.
• Experience with sample preparation, experimental design, library construction, sequencing workflows, and quality control for genomics applications.
• Strong understanding of immunology, inflammation, cancer biology, and immune mechanisms relevant to therapeutic target discovery and translational research.
• Strong experience analyzing and interpreting complex multi-omics datasets using tools such as R, Python, Seurat, Scanpy, Bioconductor, Cell Ranger, ArchR, Signac, or related bioinformatics platforms.
• Experience with cell line engineering, in vitro cell-based immunology assays and high-throughput cell-based screening is a plus.
• Experience in autoimmune disease, inflammatory disorders, tumor immunology, or immuno-oncology is preferred.
• Experience with spatial transcriptomics, multiplex imaging, spatial proteomics, or other advanced tissue profiling technologies is highly desirable.
• Familiarity with machine learning, artificial intelligence, large-scale biological foundation models, or AI-enabled target discovery approaches is a strong plus.
• Ability to operate effectively in a highly collaborative, fast-paced, and interdisciplinary research environment, and to integrate multi-disciplinary approaches to solve complex biological problems.
• Strong collaboration skills across functional and disciplinary boundaries.
• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences.

Education required:

Ph.D., M.D., or equivalent advanced degree

Travel: No

Global competencies

When we exhibit our values of patients first, driving excellence, bold ingenuity, and collaborative spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters teamwork
• Provides and solicits honest and actionable feedback
• Self-awareness
• Acts inclusively
• Demonstrates initiative
• Entrepreneurial mindset
• Continuous learning
• Embraces change
• Results-oriented
• Analytical thinking/data analysis
• Financial excellence
• Communicates with clarity

Salary range: $150,200.00 – $187,800.00 annually

BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non-commercial roles are eligible to participate in the annual bonus plan, and commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes medical, dental, vision, 401(k), FSA/HSA, life insurance, paid time off, and wellness.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact accommodationsus@beonemed.com.