Senior Scientist Translational ADME Full-time NEW

Senior Scientist

Johnson & Johnson Innovative Medicine (J&J IM) is dedicated to developing transformative treatments that enhance health for individuals around the globe. Our diverse research and development initiatives cover a range of fields, including immunology, oncology, neuroscience, cardio-pulmonology, and communicable diseases. Our mission is clear: to empower people to live longer, healthier lives. With a legacy of introducing numerous first-in-class prescription medications, we are well-positioned to meet the extensive needs of the healthcare sector—serving everyone from patients to practitioners, and from clinics to hospitals.

We are currently seeking a Senior Scientist to join our Global Translational ADME group, an area within the Translational Pharmacokinetics (PK)/Pharmacodynamics (PD) & Investigative Toxicology (TPPIT) department. The team provides project teams with mechanistic understanding and integrated interpretation of in vitro and in vivo ADME properties, drug-drug interaction (DDI) liabilities (enzymes and transporters), and the relationship between PK/toxicokinetics and PD response to support key decisions for discovery and development projects.

The Translational ADME team in Beerse is seeking a highly motivated scientist to strengthen translational ADME capabilities, specifically advancing clearance predictions through novel in vitro–in vivo extrapolation (IVIVE) approaches for small molecules and other emerging modalities such as degraders, RipTacs, and peptides. In this role you will be employing sophisticated ex vivo techniques and complex in vitro models (CIVM), developing innovative in vitro methods and mechanistic modelling approaches to enhance our understanding of transporter and enzyme interplay and their contribution to hepatic clearance and DDI. Strong subject matter expertise and hands-on experience with ex vivo techniques and hepatocyte culture models, plus quantitative mechanistic modeling experience is expected, including PBPK/IVIVE-linked approaches. This position will require hands-on lab work, while also offering ample scientific leadership and personal growth opportunities through training, mentoring and R&D-wide connectivity. Additionally, you will be authoring reports and scientific publications and present data to the scientific community both internally and externally.

Required Qualifications

• Required Minimum Education: PhD
• Required Years of Related Experience: +4 (including PhD)

Required Knowledge, Skills, and Abilities:

• Education: PhD in Pharmaceutical Sciences, Biology, Pharmacology, Biomedical Sciences or equivalent.
• Technical Expertise: Hands-on experience with ex vivo and in vitro liver (e.g. hepatocytes, next generation 2D and 3D fluidics models). Hands-on experience in in vitro enzymology, drug transporters, drug metabolism, disposition studies. Hands-on experience in bioanalytical assay development (LC/MS).
• Methodological Skills: Experience of modelling cellular processes. Basic knowledge and strong interest in PBPK and PK/PD are required.
• Innovative thinking: Ability to independently diagnose and design specific tailor-made study packages to tackle complex compound-specific problems.
• Scientific Curiosity: High degree of scientific curiosity and creativity to tackle complex investigational hypotheses.
• Project Management: Capability to manage multiple divergent research lines while maintaining oversight of project timelines and status.
• Interpersonal Skills: Strong interpersonal skills necessary for facilitating efficient interactions with both internal teams and external collaborators.

Required Skills:

Analytical Reasoning, Clinical Data Management, Clinical Pharmacology, Clinical Trials Operations, Coaching, Critical Thinking, Drug Discovery Development, Empowering People, Pharmacokinetic Modeling, Pharmacokinetics, Pharmacology, Pharmacometrics, Program Management, Report Writing, Scientific Research, Technologically Savvy

The anticipated base pay range for this position is:

€72,500.00 – €115,230.00

Benefits:

In addition to base pay, we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees' and companies' performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees – and in some location's eligible dependents – can participate in several insurance plans. For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.