Sr Scientist I – Biopharmaceutics Full-time NEW

AbbVie Senior Scientist I

AbbVie's Molecular Profiling and Drug Delivery (MPDD) organization is seeking a highly motivated, talented, and creative scientist with expertise and experience in biopharmaceutics, pharmaceutical science, and drug delivery for a Senior Scientist I position. The primary role of this position is to serve as a biopharm project leader within MPDD to support discovery and early clinical programs and lead peptide oral delivery programs.

The successful candidate will lead CMC developability assessment for emerging molecules on peptide and small molecule pipeline programs. This role will also entail contributing towards developing our drug delivery capabilities with a focus on complex chemically synthesized modalities. This person will be working collaboratively with discovery and development partners across disciplines to improve delivery of these modalities and advance molecules to clinical development with improved developability profiles.

The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on developability, preclinical and/or clinical formulation, biopharmaceutics, and drug delivery concepts relevant to small molecules and peptides.

Qualifications:

• Senior Scientist I typically requires Bachelors, Masters, or Ph.D. with 10+ (B.S.), 8+ (M.S.), and 1-3 (Ph.D.) years of experience in pharmaceutical or related industry. Preferred educational backgrounds include but are not restricted to Pharmaceutical Sciences, Pharmaceutical Engineering, Chemical/ Biomedical Engineering, and Materials Science.
• Fundamental understanding of biopharmaceutics as it relates to drug absorption across routes of administration including biorelevant dissolution testing, ex vivo permeability assessment, and peptide aggregation.
• Familiarity and preferred hands-on experience in physicochemical property assessment related to understanding CMC developability profile and potential risk mitigation strategies. Techniques of interest include, but are not limited to: chromatography, DSF, rat intestinal perfusion, Ussing Chambers, Franz Diffusion cells, X-ray diffraction, thermal analysis, microscopy, biophysical characterization techniques, etc.
• Experience developing and characterizing drug delivery systems to improve the bioperformance of peptides, in particular the use of permeation enhancer formulations.
• Experience supporting GLP toxicology studies for oral peptide development.
• Knowledge of preclinical and clinical formulation development principles relevant to chemically synthesized molecules across routes of administration.
• Excellent self-management and organizational skills.
• Demonstrated strong communication skills and ability to clearly communicate theories and concepts, influence others without authority, and drive technical excellence.

Compensation range: $96,500 – $183,500 USD